Evidence map›Paper›PMID 39754023›Full record

ArticleScientific reports2025

Cinnamic acid conjugated with triazole acetamides as anti-Alzheimer and anti-melanogenesis candidates: an in vitro and in silico study.

Amir Shervin Shokouhi Asl, Mohammad Hosein Sayahi, Mohammad Hashem Hashempur, Cambyz Irajie, Amir Hossein Alaeddini, Seyedeh Niloufar Ghafouri, Milad Noori, Navid Dastyafteh, Javad Mottaghipisheh, Mehdi Asadi and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The connection between autophagy and Alzheimer's disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
  5. Enzymatic, cell-based, andRSC advances · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Amir Shervin Shokouhi AslDepartment of Medicinal Chemistry, School of Pharmacy, Iran University of Medical Sciences, Tehran, Iran.
Mohammad Hosein SayahiDepartment of Chemistry, Payame Noor University, Tehran, Iran.
Mohammad Hashem HashempurResearch Center for Traditional Medicine and History of Medicine, Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Cambyz IrajieDepartment of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
Amir Hossein AlaeddiniSchool of Chemistry, College of Science, University of Tehran, Tehran, Iran.
Seyedeh Niloufar GhafouriSchool of Chemistry, College of Science, University of Tehran, Tehran, Iran.
Milad NooriEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Navid DastyaftehEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Javad MottaghipishehDepartment of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences, 7050, SE-750 07, Uppsala, Sweden.
Mehdi AsadiDepartment of Medicinal Chemistry, School of Pharmacy, Iran University of Medical Sciences, Tehran, Iran.
Bagher LarijaniDepartment of Medicinal Chemistry, School of Pharmacy, Iran University of Medical Sciences, Tehran, Iran.
Mohammad MahdaviEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. momahdavi@sina.tums.ac.ir.
Aida IrajiStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. aida.iraji@gmail.com.

Funding

Vice-Chancellor for Research, Shiraz University of Medical Sciences 31394
6 · The paper itself

Abstract

In this study, new cinnamic acid linked to triazole acetamide derivatives was synthesized and evaluated for anti-Alzheimer and anti-melanogenesis activities. The structural elucidation of all analogs was performed using different analytical techniques, including

Indexed as

AcetamidesAlzheimer DiseaseCinnamatesMolecular Docking SimulationMonophenol MonooxygenaseTriazolesAcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsComputer SimulationHumansStructure-Activity RelationshipAcetamidesAcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsCinnamatescinnamic acidMonophenol MonooxygenaseTriazolesAcetylcholinesteraseAlzheimer’s diseaseButyrylcholinesteraseCinnamic acidKinetictriazole acetamideTyrosinase

Identifiers

PMID39754023
PMCPMC11698978

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.