ArticleNature communications2025
A modular approach to catalytic stereoselective synthesis of chiral 1,2-diols and 1,3-diols.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Regio-, Stereo-, and Enantioselective C(spAngewandte Chemie (International ed. in English) · 2026Article
- Synergistic decatungstate and Brønsted acid catalysis enables direct C-H indolation of alkanes and aldehydes.Chemical science · 2026Article
- Substitutive Approach Toward Heteroaromatic Amino Alcohols Accessed Through Dioxolanyl Radical Linchpin.Advanced synthesis & catalysis · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
Optically pure 1,2-diols and 1,3-diols are the most privileged structural motifs, widely present in natural products, pharmaceuticals and chiral auxiliaries or ligands. However, their synthesis relies on the use of toxic or expensive metal catalysts or suffer from low regioselectivity. Catalytic asymmetric synthesis of optically pure 1,n-diols from bulk chemicals in a highly stereoselective and atom-economical manner remains a formidable challenge. Here, we disclose a versatile and modular method for the synthesis of enantioenriched 1,2-diols and 1,3-diols from the high-production-volume chemicals ethane-1,2-diol (MEG) and 1,3-propanediol (PDO), respectively. The key to success is to temporarily mask the diol group as an acetonide, which imparts selectivity to the key step of C(sp
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Registered trials
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