ArticleNature chemistry2025
Stereoselective amino alcohol synthesis via chemoselective electrocatalytic radical cross-couplings.
Article in Nature chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Organocatalytic enantioselective synthesis and derivatizations of bridgedChemical science · 2026Article
- Unlocking Interfacial Catalytic Halogen Atom Transfer at Ag Electrodes with Brønsted Acids.Journal of the American Chemical Society · 2026Article
- Cross-Electrophile Coupling ofJournal of the American Chemical Society · 2026Article
- Photocatalytic Minisci Approach to Chiral 2-Hetaryl-1,2-aminoalcohols from β-Hydroxy-α-amino Acid-Derived Redox Active Esters.The Journal of organic chemistry · 2025Article
- Use of Electron-Transfer Mediators to Access Higher Electrochemical Current Densities in Ni-Catalyzed Cross-Electrophile Coupling.Journal of the American Chemical Society · 2025Article
- A sustainable electrochemical phosphonylation of phenothiazine. Synthesis of a C-phosphonium betaine with powerful antibacterial activity.RSC advances · 2025Article
- Green electrochemical late-stage sulfonylation of clonazepam an anticonvulsant benzodiazepine drug.Scientific reports · 2025Article
- Stereoselective Biosynthesis of Bichiral Amino Alcohols from Diketone via Difunctionalization.ACS omega · 2025Article
- Electrochemically induced Meerwein arylation as a green strategy for the synthesis of arylbenzoquinone derivatives under batch and flow conditions.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Amino alcohols are vital in natural products, pharmaceuticals and agrochemicals, and as key building blocks for various applications. Traditional synthesis methods often rely on polar bond retrosynthetic analysis, requiring extensive protecting group manipulations that complicate direct access. Here we show a streamlined approach using a serine-derived chiral carboxylic acid in stereoselective electrocatalytic decarboxylative transformations, enabling efficient access to enantiopure amino alcohols. Unlike conventional strategies, this radical method is both modular and general, offering stereoselective and chemoselective synthesis of diverse substituted amino alcohols. For example, aryl, alkenyl, alkyl and acyl fragments can be coupled efficiently with the serine-derived chiral acid under electrocatalytic decarboxylative conditions. We demonstrate its utility through the rapid synthesis of medicinally important compounds, as well as useful building blocks, highlighting its ability to simplify complex synthetic pathways through entirely different bond disconnections. This electrocatalytic method is robust and scalable, as demonstrated in a 72-gram-scale flow reaction.
Identifiers
39754013What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.