ArticleEating and weight disorders : EWD2025
Evaluating the weight-adjusted waist index as a predictive tool for sarcopenia and mortality risk.
Article in Eating and weight disorders : EWD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Associations and predictive value of weight-adjusted waist index for cardiovascular outcomes in type 2 diabetes: evidence from the ACCORD study.Nutrition journal · 2025Trial
- Composite C-reactive protein-triglyceride-glucose-adiposity indices and incident cardiovascular disease in the CHARLS cohort: a prospective cohort study.Cardiovascular diabetology · 2026Article
- Biomarkers of aging: from molecules and surrogates to physiology and function.Physiological reviews · 2025Review
- Weight-adjusted waist circumference index and chronic diseases as predictors of depression risk in U.S. adults: a cross-sectional study with mediation analysis.Frontiers in nutrition · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
purposeThe weight-adjusted waist index (WWI) is a novel anthropometric measure. WWI is linked to reduced muscle mass and strength; however, its efficacy for assessing sarcopenia and predicting adverse outcomes has yet to be validated. This study compared and examined the relationship between sarcopenia and WWI across different diagnostic criteria and aimed to evaluate its potential as a predictor of sarcopenia and all-cause mortality.
methodsThis study used data from 2946 NHANES (1999-2002) participants to analyze the relationship between weight-adjusted waist index (WWI) and sarcopenia (diagnosed using five different established criteria). Multivariable logistic regression, ROC analysis, Kaplan-Meier curves, and Cox regression were used to assess the association between WWI and sarcopenia and mortality.
resultsWWI was inversely correlated with walking speed, muscle strength, and muscle mass. It served as a significant predictor of sarcopenia, particularly in men, with an area under the ROC curve (AUC) of 0.86 for men according to FNIH criteria. Furthermore, a higher mortality rate from all causes was linked to a higher WWI. The mortality rate among patients with sarcopenia, as predicted by the WWI and FNIH criteria, was higher than that of patients diagnosed by a single criterion.
conclusionsWWI proves to be a valuable tool in predicting sarcopenia and mortality risk, particularly when using the FNIH criteria. However, its performance varied significantly across different criteria and populations. Further research is needed to define the specific clinical contexts where WWI may be a useful supplementary tool. Level of Evidence Level III, evidence obtained from a cohort analytic study.
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