ArticleNature cardiovascular research2025
Cardiac conduction system regeneration prevents arrhythmias after myocardial infarction.
Article in Nature cardiovascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Magneto-responsive piezoelectric CoFeMaterials today. Bio · 2026Article
- NEAT1 Coordinates a PDLIM5-CACNA1C Regulatory Program Associated with a Potentially Arrhythmogenic Cardiomyocyte State in the Border Zone During Early Myocardial Infarction.International journal of molecular sciences · 2026Article
- Post-MI Remodeling Mechanics of Left Ventricle: Microstructure-Informed Models, Identifiability, and Uncertainty for Patient-Specific Prediction.Bioengineering (Basel, Switzerland) · 2026Review
- Cardiac Resynchronization Therapy: A Review.JAMA · 2026Review
- The cardiac conduction system: development, function and therapeutic targets.Nature reviews. Cardiology · 2026Review
- In silico assessment of arrhythmic risk following the implantation of engineered heart tissues in porcine hearts with varying infarct locations.PLoS computational biology · 2026Article
- Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Optoelectronic Interfaces for Nongenetic Modulation of Excitable Tissues.Small methods · 2026Review
- Genomic Structural Equation Modeling Combined With Post-GWAS Analysis Identifies Two Risk Gene Loci and Functionally Sensitive Genes Associated With Cardiac Conduction Block.Genetics research · 2026Article
- Multifunctional applications of hydrogel materials in myocardial infarction treatment: from tissue repair to microenvironment regulation.RSC advances · 2025Review
- Immune-mediated cardiac development and regeneration.Seminars in cell & developmental biology · 2025Review
- Conduction system regeneration and remodeling after myocardial infarction.Nature cardiovascular research · 2025Article
- Tapered fiber probe-based optical cardiac pacemaker.Frontiers in bioengineering and biotechnology · 2025Article
- Comparing the effects of left bundle branch pacing and leadless right ventricular pacing on intraventricular and interventricular dyssynchrony usingFrontiers in physiology · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Arrhythmias are a hallmark of myocardial infarction (MI) and increase patient mortality. How insult to the cardiac conduction system causes arrhythmias following MI is poorly understood. Here, we demonstrate conduction system restoration during neonatal mouse heart regeneration versus pathological remodeling at non-regenerative stages. Tissue-cleared whole-organ imaging identified disorganized bundling of conduction fibers after MI and global His-Purkinje disruption. Single-cell RNA sequencing (scRNA-seq) revealed specific molecular changes to regenerate the conduction network versus aberrant electrical alterations during fibrotic repair. This manifested functionally as a transition from normal rhythm to pathological conduction delay beyond the regenerative window. Modeling in the infarcted human heart implicated the non-regenerative phenotype as causative for heart block, as observed in patients. These findings elucidate the mechanisms underpinning conduction system regeneration and reveal how MI-induced damage elicits clinical arrhythmogenesis.
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Registered trials
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