Article in Nature cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Shingo KajimuraDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0672-5910
Anna SchmokerDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Structure, mechanism, and pharmacology of BRAF and its partners in the RAS/RAF/MAP kinase pathwayR35CA242461 · NCI · DANA-FARBER CANCER INST · PI ECK, MICHAEL J · 2019 to 2025
$7.4M
Molecular mechanisms of UCP1-independent pathways in metabolic healthR01DK097441 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Shingo Kajimura · 2012 to 2026
$5.9M
P&F programP30DK135043 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Deborah J Wexler · 2023 to 2026
$5.4M
Transcriptional Control of Mitochondrial Bioenergetic FunctionR01DK081418 · NIDDK · DANA-FARBER CANCER INST · PI PUIGSERVER, PERE · 2008 to 2021
$5.2M
Molecular, Cellular, and Developmental MechanismsT32GM145407 · NIGMS · HARVARD MEDICAL SCHOOL · PI David L. Van Vactor · 2022 to 2026
$5.2M
Mitochondrial Metabolite Compartmentalization in Health and DiseaseDP1DK126160 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAJIMURA, SHINGO · 2020 to 2025
$4.4M
Insulin Signaling and Metabolic Effects through CLK2 KinaseR01DK089883 · NIDDK · DANA-FARBER CANCER INST · PI PUIGSERVER, PERE · 2011 to 2020
$3.8M
Regulatory mechanisms of mitochondrial cristae biogenesis and thermogenic functionR01DK136640 · NIDDK · DANA-FARBER CANCER INST · PI Pere Puigserver · 2023 to 2026
$2.7M
A liver-specific mitochondrial carrier that controls energy homeostasisR01DK138529 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Shingo Kajimura · 2024 to 2026
$2.1M
CalRepository: A database of indirect calorimetry experiments for the study of energy homeostasisR01DK133948 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BANKS, ALEXANDER · 2022 to 2025
$2.0M
Mitochondrial BCAA transporter in physiology and diseaseR01DK125283 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAJIMURA, SHINGO · 2021 to 2025
$1.8M
Instrumentation for Noninvasive Measurement of Glucose and Energy Balance in Mice with Continuous Glucose Telemetry and Indirect CalorimetryS10OD028635 · OD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BANKS, ALEXANDER · 2020 to 2020
$737k
American Heart Association (American Heart Association, Inc.) 24POST1198357American Heart Association-American Stroke Association 24POST1198357NCI NIH HHS R35 CA242461NIDDK NIH HHS DP1 DK126160NIDDK NIH HHS K99 DK133502NIDDK NIH HHS P30 DK135043NIDDK NIH HHS R01 DK081418NIDDK NIH HHS R01 DK089883NIDDK NIH HHS R01 DK097441NIDDK NIH HHS R01 DK125283NIDDK NIH HHS R01 DK133948NIDDK NIH HHS R01 DK136640NIDDK NIH HHS R01 DK138529NIGMS NIH HHS F32 GM125243NIGMS NIH HHS T32 GM145407NIH HHS S10 OD028635U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) K99DK133502U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK081418U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK136640U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) 1T32GM145407U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM125243
6 · The paper itself
Abstract
Outer mitochondrial membrane (OMM) proteins communicate with the cytosol and other organelles, including the endoplasmic reticulum. This communication is important in thermogenic adipocytes to increase the energy expenditure that controls body temperature and weight. However, the regulatory mechanisms of OMM protein insertion are poorly understood. Here the stress-induced cytosolic chaperone PPID (peptidyl-prolyl isomerase D/cyclophilin 40/Cyp40) drives OMM insertion of the mitochondrial import receptor TOM70 that regulates body temperature and weight in obese mice, and respiratory/thermogenic function in brown adipocytes. PPID PPIase activity and C-terminal tetratricopeptide repeats, which show specificity towards TOM70 core and C-tail domains, facilitate OMM insertion. Our results provide an unprecedented role for endoplasmic-reticulum-stress-activated chaperones in controlling energy metabolism through a selective OMM protein insertion mechanism with implications in adaptation to cold temperatures and high-calorie diets.
Indexed as
MitochondriaMitochondrial Membrane Transport ProteinsMolecular ChaperonesObesityAdipocytes, BrownAnimalsDiet, High-FatEndoplasmic Reticulum StressEnergy MetabolismHumansMaleMiceMice, Inbred C57BLMice, KnockoutMitochondrial MembranesMitochondrial Precursor Protein Import Complex ProteinsMitochondrial Membrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsMolecular Chaperones
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity. · full record | OpenQuestion