Evidence map›Paper›PMID 39753885›Full record

ArticlePediatric research2025

Building a growing genomic repository for maternal and fetal health through the PING Consortium.

Clara M Abdelmalek, Shriya Singh, Blain Fasil, Allison R Horvath, Sarah B Mulkey, Carlos Curé, Maribel Campos, Denise P Cavalcanti, Van T Tong, Marcela Mercado and 29 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

39 authors.

Clara M AbdelmalekCenter for Genetic Medicine, Children's National Research Institute, Washington, DC, USA.ORCID http://orcid.org/0009-0004-4228-4678
Shriya SinghCenter for Genetic Medicine, Children's National Research Institute, Washington, DC, USA.ORCID http://orcid.org/0009-0003-4836-3310
Blain FasilCenter for Genetic Medicine, Children's National Research Institute, Washington, DC, USA.ORCID http://orcid.org/0000-0002-3488-0259
Allison R HorvathCenter for Genetic Medicine, Children's National Research Institute, Washington, DC, USA.ORCID http://orcid.org/0000-0001-6321-1014
Sarah B MulkeyDepartments of Neurology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Carlos CuréBIOMELab, Barranquilla, Colombia.ORCID http://orcid.org/0000-0002-3011-8814
Maribel CamposCenter for Community Outreach for Health Across the Lifespan, Dental and Craniofacial Genomics Core, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico.ORCID http://orcid.org/0000-0002-7744-3550
Denise P CavalcantiPerinatal Genetics Program, Department of Translational Medicine, Medical Genetics, University of Campinas, Campinas, Brazil.ORCID http://orcid.org/0000-0001-5334-0955
Van T TongDivision of Birth Defects and Infant Disorders, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-3970-1440
Marcela MercadoFacultad de Ciencias de la Salud, Universidad del Norte, Barranquilla, Colombia.
Marcela DazaUniversidad Nacional de Colombia, Bogotá, Colombia.ORCID http://orcid.org/0000-0003-4592-2685
Mónica Marcela BenavidesInstituto Nacional de Salud, Bogotá, Colombia.ORCID http://orcid.org/0000-0001-6287-6495
Jacqueline AcostaVysnova Partners, Inc., Landover, MD, USA.
Suzanne GilboaDivision of Birth Defects and Infant Disorders, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-7092-6667
Diana ValenciaDivision of Preparedness and Emerging Infections, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-9578-3751
Christina L SanckenDivision of Birth Defects and Infant Disorders, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Suzanne NewtonDivision of Birth Defects and Infant Disorders, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Deolinda M F ScalabrinDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-4451-8632
Marisa M Mussi-PinhataDepartment of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.ORCID http://orcid.org/0000-0001-8985-1570
Zilton VasconcelosInstituto Fernandes Figueira, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0002-2193-2224
Nahida ChakhtouraPregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Jack MoyeMaternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-9976-8586
Elizabeth J LeslieDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-5735-1712
Dorothy BulasDepartment of Radiology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.ORCID http://orcid.org/0000-0001-5003-2105
Gilbert VezinaDepartment of Radiology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Fernanda J P MarquesSARAH Network of Rehabilitation Hospitals, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0001-6826-7084
Marcio LeyserStead Family Department of Pediatrics, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0002-2929-8416
Miguel Del CampoDepartment of Pediatrics, Division of Genetics, University of California, San Diego and Rady Children's Hospital-San Diego, San Diego, California, USA.
Eric VilainInstitute for Clinical and Translational Science, University of California, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-5557-3709
Roberta L DeBiasiDivision of Pediatric Infectious Diseases, Children's National Hospital, Washington, DC, USA.ORCID http://orcid.org/0000-0002-5854-8875
Tongguang WangTranslational Neuroscience Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-0195-5661
Avindra NathTranslational Neuroscience Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-0927-5855
Tarik HaydarCenter for Neuroscience Research, Children's National Research Institute, Washington, DC, USA.ORCID http://orcid.org/0000-0001-6772-3076
Max MuenkeNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-7719-6545
Tamer A MansourDepartment of Population Health and Reproduction, University of California, Davis, CA, USA.ORCID http://orcid.org/0000-0002-4747-4241
Adre J du PlessisDepartments of Neurology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.ORCID http://orcid.org/0000-0003-3144-8791
Jeffrey C MurrayStead Family Department of Pediatrics, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0001-6346-6551
José F CorderoDepartment of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, USA.ORCID http://orcid.org/0000-0002-0564-6391
Youssef A KousaCenter for Genetic Medicine, Children's National Research Institute, Washington, DC, USA. YKousa@ChildrensNational.org.ORCID http://orcid.org/0000-0001-6049-8144

Funding

Childhood Outcome After In Utero ZIKV ExposureR01HD102445 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI MULKEY, SARAH BETH · 2020 to 2024
$3.6M
Viral Neurobiology in the Prenatal BrainK08NS119882 · NINDS · CHILDREN'S RESEARCH INSTITUTE · PI Youssef A Kousa · 2022 to 2026
$1.1M
Dental and Craniofacial Effects of Intrauterine Zika Virus InfectionR21DE027235 · NIDCR · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CAMPOS-RIVERA, MARIBEL · 2017 to 2019
$838k
Intramural CDC HHS CC999999NICHD NIH HHS L40 HD102847NICHD NIH HHS R01 HD102445NIDCR NIH HHS R21 DE027235NINDS NIH HHS K08 NS119882
6 · The paper itself

Abstract

backgroundPrenatally transmitted viruses can cause severe damage to the developing brain. There is unexplained variability in prenatal brain injury and postnatal neurodevelopmental outcomes, suggesting disease modifiers. Of note, prenatal Zika infection can cause a spectrum of neurodevelopmental disorders, including congenital Zika syndrome. Currently, there is no preventative treatment or cure. The Prenatal Infection and Neurodevelopmental Genetics (PING) Consortium aims to identify modulators of brain injury and adverse neurodevelopmental outcomes for Zika and other prenatal viral infections.

methodsThe Consortium pools information from eight multi-site studies conducted at 23 research centers in six countries to build a growing clinical and genomic repository, which is being mined for modifiers of virally induced brain injury. Partners include Children's National Hospital (USA), Instituto Nacional de Salud (Colombia), the Natural History of Zika Virus Infection in Gestation program (Brazil), Zika Instituto Fernandes Figueira (Brazil), the Centers for Disease Control and Prevention, and the National Institutes of Health.

resultsWe have enrolled 4102 mothers and 3877 infants with 3063 biological samples and clinical data covering over 80 phenotypic fields and 5000 variables. Thus far, we have performed whole exome sequencing on 1226 participants.

conclusionHere, we present the Consortium's formation and overarching study design. IMPACT: The PING Consortium brings together investigators and institutions to determine the causes of virally induced brain injury and neurological deficits. The clinical and genomic repository, with data from over 8000 patients, will serve as a foundation for a variety of basic and clinical studies.

Indexed as

Biological Specimen BanksFetal ResearchGenetic ResearchNeurodevelopmental DisordersPregnancy Complications, InfectiousVirus DiseasesAdultBrain InjuriesBrazilColombiaDatabases, GeneticEpidemiologic Research DesignExome SequencingFemaleHumansInfant, Newborn

Identifiers

PMID39753885
PMCPMC12222536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.