ArticleNature genetics2025
Blood DNA virome associates with autoimmune diseases and COVID-19.
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In one paragraph
Article in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Genetic basis of Asian diabetes.Journal of diabetes investigation · 2026Review
- Association between clinical symptoms and time to pharyngeal PCR negativity among mild omicron COVID-19 patients: a retrospective study.BMC infectious diseases · 2026Article
- Cross-Compartment Virome Profiling in Human Immunodeficiency Virus Infection and Substance Use Disorder Reveals Brain-CSF-Periphery Discordance and Hepatitis B Virus in Central Nervous System.International journal of molecular sciences · 2026Article
- A viral APOBEC3 antagonist distinguishes HHV-6A from HHV-6B.Nature communications · 2026Article
- The Human Virome in Infectious Diseases: Insights from Chronic and Acute Infections Across Body Sites-A Narrative Review.Microorganisms · 2026Review
- A long-term observational study on autoimmune pulmonary alveolar proteinosis revealed a sustained and generalized decrease in serum autoantibody levels.Orphanet journal of rare diseases · 2026Observational
- Article
- Article
- Human herpesvirus 7 and the risk of developing multiple sclerosis.Brain communications · 2026Article
- Ocrelizumab transiently alters microbiota and modulates immune response depending on treatment outcome.iScience · 2025Article
- Host Genetic Architecture between Epstein-Barr Virus Activity and Multiple Sclerosis Reveals Shared Pathways.medRxiv : the preprint server for health sciences · 2025Article
- Whole-genome sequencing reveals rare and structural variants contributing to psoriasis and identifies CERCAM as a risk gene.Cell genomics · 2025Article
- Discovery of diverse anellovirus sequences in Thai human sequencing data.Microbiology spectrum · 2025Article
- Endogenous human herpesviruses 6A/B.Journal of virology · 2025Article
- Inherited chromosomally integrated human herpesvirus 6: regional variation in prevalence, association with angina, and identification of ancestral viral lineages in two large UK studies.Journal of virology · 2025Article
- Population-scale sequencing resolves correlates and determinants of latent Epstein-Barr Virus infection.bioRxiv : the preprint server for biology · 2025Article
- Overview of Microorganisms: Bacterial Microbiome, Mycobiome, Virome Identified Using Next-Generation Sequencing, and Their Application to Ophthalmic Diseases.Microorganisms · 2025Review
- The human plasma anellome exhibits age- and sex-dependent patterns with links to cardiometabolic health in older adults.Frontiers in microbiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
133 authors.
Noah Sasa *Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Shohei Kojima *Genome Immunobiology RIKEN Hakubi Research Team, RIKEN Center for Integrative Medical Sciences and RIKEN Cluster for Pioneering Research, Yokohama, Japan.ORCID 0000-0002-6764-4818
Rie Koide *Genome Immunobiology RIKEN Hakubi Research Team, RIKEN Center for Integrative Medical Sciences and RIKEN Cluster for Pioneering Research, Yokohama, Japan.
Takanori HasegawaM&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan.ORCID 0000-0001-7251-9950
Ho NamkoongDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.ORCID 0000-0001-6181-4284
Tomomitsu HirotaDivision of Molecular Genetics, Research Center for Medical Science, The Jikei University School of Medicine, Tokyo, Japan.
Rei WatanabeDepartment of Integrative Medicine for Allergic and Immunological Diseases, Osaka University Graduate School of Meidince, Suita, Japan.
Yuumi NakamuraDepartment of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan.ORCID 0000-0001-6256-8302
Eri Oguro-IgashiraDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Kotaro OgawaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Tomohiro YataDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Kyuto SoneharaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.ORCID 0000-0002-4536-1761
Kenichi YamamotoDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.ORCID 0000-0001-9594-7050
Toshihiro KishikawaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Saori SakaueDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.ORCID 0000-0003-3618-9717
Ryuya EdahiroDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Yuya ShiraiDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.ORCID 0000-0002-0518-9020
Yuichi MaedaDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Takuro NiiDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Shotaro ChubachiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Hiromu TanakaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Haruka YabukamiGenome Immunobiology RIKEN Hakubi Research Team, RIKEN Center for Integrative Medical Sciences and RIKEN Cluster for Pioneering Research, Yokohama, Japan.
Akari SuzukiLaboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Kimiko NakajimaDepartment of Dermatology, Kochi Medical School, Kochi University, Nankoku, Japan.
Noriko AraseDepartment of Dermatology, Osaka University Graduate School of Medicine, Suita, Japan.
Takashi OkamotoDepartment of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Rika NishikawaDivision of Dermatology, Department of Internal Related, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Shinichi NambaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.ORCID 0000-0002-7486-3146
Tatsuhiko NaitoDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.ORCID 0000-0002-2779-4600
Ippei MiyagawaThe First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Hiroaki TanakaThe First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.ORCID 0000-0003-3022-1317
Masanobu UenoThe First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Yosuke IshitsukaDepartment of Integrative Medicine for Allergic and Immunological Diseases, Osaka University Graduate School of Meidince, Suita, Japan.
Junichi FurutaDepartment of Dermatology, University of Tsukuba, Tsukuba, Japan.ORCID 0000-0002-3502-5780
Kayo KunimotoDepartment of Dermatology, Wakayama Medical University Graduate School of Medicine, Wakayama, Japan.ORCID 0000-0001-8102-1193
Ikko KajiharaDepartment of Dermatology and Plastic Surgery, Kumamoto University, Kumamoto, Japan.
Satoshi FukushimaDepartment of Dermatology and Plastic Surgery, Kumamoto University, Kumamoto, Japan.ORCID 0000-0002-0622-7682
Hideaki MiyachiDepartment of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan.ORCID 0000-0003-2549-6690
Hiroyuki MatsueDepartment of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan.
Masahiro KamataDepartment of Dermatology, Teikyo University School of Medicine, Tokyo, Japan.
Mami MomoseDepartment of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.
Toshinori BitoDivision of Dermatology, Department of Internal Related, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Hiroshi NagaiDivision of Dermatology, Department of Internal Related, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Tetsuya IkedaDepartment of Dermatology, Kobe City Hospital Organization Kobe Medical Center West Hospital, Kobe, Japan.
Tatsuya HorikawaDepartment of Dermatology, Nishikobe Medical Center, Kobe, Japan.
Atsuko AdachiDepartment of Dermatology, Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Japan.
Tsukasa MatsubaraMatsubara Mayflower Hospital, Kato, Japan.
Kyoko IkumiDepartment of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Emi NishidaDepartment of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Ikuma NakagawaHokkaido Medical Center for Rheumatic Diseases, Sapporo, Japan.
Mayu Yagita-SakamakiDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Maiko YoshimuraDepartment of Rheumatology, NHO Osaka Minami Medical Center, Kawachinagano, Japan.
Shiro OhshimaDepartment of Rheumatology, NHO Osaka Minami Medical Center, Kawachinagano, Japan.
Makoto KinoshitaDepartment of Neurology, Osaka University Graduate School of Medicine, Suita, Japan.
Satoru ItoDivision of Respiratory Medicine and Allergology, Department of Internal Medicine, School of Medicine, Aichi Medical University, Aichi, Japan.ORCID 0000-0001-7885-4653
Toru AraiClinical Research Center, NHO Kinki Chuo Chest Medical Center, Sakai, Japan.ORCID 0000-0002-2222-0683
Masaki HiroseClinical Research Center, NHO Kinki Chuo Chest Medical Center, Sakai, Japan.
Yoshinori TaninoDepartment of Pulmonary Medicine, Fukushima Medical University, Fukushima, Japan.ORCID 0000-0003-2384-601X
Takefumi NikaidoDepartment of Pulmonary Medicine, Fukushima Medical University, Fukushima, Japan.
Toshio IchiwataDepartment Respiratory Medicine, Tokyo Medical University, Tokyo, Japan.
Shinya OhkouchiDepartment of Occupational Health, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID 0000-0002-4658-6487
Taizou HiranoHirosaki Medical Center, Hirosaki, Japan.
Toshinori TakadaUonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan.
Ryushi TazawaStudent Support and Health Administration Organization, Tokyo Medical and Dental University, Tokyo, Japan.ORCID 0000-0002-4580-004X
Konosuke MorimotoDepartment of Respiratory Infections, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Masahiro TakakiDepartment of Infectious Diseases, Nagasaki University Hospital, Nagasaki University, Nagasaki, Japan.
Satoshi KonnoDepartment of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Masaru SuzukiDepartment of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Keisuke TomiiDepartment of Respiratory Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
Atsushi NakagawaDepartment of Respiratory Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
Tomohiro HandaDepartment of Advanced Medicine for Respiratory Failure, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kiminobu TanizawaDepartment of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Haruyuki IshiiDepartment of Respiratory Medicine, Kyorin University Faculty of Medicine, Mitaka, Japan.
Manabu IshidaDepartment of Respiratory Medicine, Kyorin University Faculty of Medicine, Mitaka, Japan.
Toshiyuki KatoDepartment of Respiratory Medicine and Allergology, Kariya Toyota General Hospital, Kariya, Japan.
Naoya TakedaDepartment of Respiratory Medicine and Allergology, Kariya Toyota General Hospital, Kariya, Japan.
Koshi YokomuraDepartment of Respiratory Medicine, Respiratory Disease Center, Seirei Mikatahara General Hospital, Hamamatsu, Japan.
Takashi MatsuiDepartment of Respiratory Medicine, Respiratory Disease Center, Seirei Mikatahara General Hospital, Hamamatsu, Japan.
Akifumi UchidaDepartment of Pulmonary Medicine, Graduate School of Medical & Dental Sciences, Kagoshima University, Kagoshima, Japan.
Hiromasa InoueDepartment of Pulmonary Medicine, Graduate School of Medical & Dental Sciences, Kagoshima University, Kagoshima, Japan.ORCID 0000-0001-8080-3812
Kazuyoshi ImaizumiDepartment of Respiratory Medicine, Fujita Health University School of Medicine, Aichi, Japan.ORCID 0000-0002-3790-8691
Yasuhiro GotoDepartment of Respiratory Medicine, Fujita Health University School of Medicine, Aichi, Japan.ORCID 0000-0003-2235-8567
Hiroshi KidaDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Tomoyuki FujisawaSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.ORCID 0000-0002-8809-1781
Takafumi SudaSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Takashi YamadaDepartment of Respiratory Medicine, Shizuoka City Shizuoka Hospital, Shizuoka, Japan.
Yasuomi SatakeDepartment of Respiratory Medicine, Shizuoka City Shizuoka Hospital, Shizuoka, Japan.
Hidenori IbataDepartment of Respiratory Medicine, National Hospital Organization Mie Chuo Medical Center, Tsu, Japan.
Mika SaigusaDepartment of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan.
Toshihiro ShiraiDepartment of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan.
Nobuyuki HizawaDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Koh NakataDivision of Advanced Medical Development, Niigata University Medical and Dental Hospital, Niigata, Japan.
Japan COVID-19 Task Force
Shinichi ImafukuDepartment of Dermatology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Yayoi TadaDepartment of Dermatology, Teikyo University School of Medicine, Tokyo, Japan.
Yoshihide AsanoDepartment of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shinichi SatoDepartment of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Chikako NishigoriDivision of Dermatology, Department of Internal Related, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Masatoshi JinninDepartment of Dermatology, Wakayama Medical University Graduate School of Medicine, Wakayama, Japan.
Hironobu IhnDepartment of Dermatology and Plastic Surgery, Kumamoto University, Kumamoto, Japan.
Akihiko AsahinaDepartment of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.
Hidehisa SaekiDepartment of Dermatology, Nippon Medical School, Tokyo, Japan.
Tatsuyoshi KawamuraDepartment of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.ORCID 0000-0003-4008-2322
Shinji ShimadaDepartment of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Ichiro KatayamaDepartment of Dermatology, Osaka University Graduate School of Medicine, Suita, Japan.
Hannah M PoisnerDivision of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0003-1652-3642
Taralynn M MackDivision of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0003-1043-2950
Alexander G BickDivision of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0001-5824-9595
Koichiro HigasaCenter for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Tatsusada OkunoDepartment of Neurology, Osaka University Graduate School of Medicine, Suita, Japan.
Hideki MochizukiDepartment of Neurology, Osaka University Graduate School of Medicine, Suita, Japan.ORCID 0000-0002-0874-7542
Makoto IshiiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.ORCID 0000-0003-4396-1664
Ryuji KoikeHealth Science Research and Development Center (HeRD), Tokyo Medical and Dental University, Tokyo, Japan.
Akinori KimuraInstitute of Research, Tokyo Medical and Dental University, Tokyo, Japan.ORCID 0000-0002-4933-2132
Emiko NoguchiDepartment of Medical Genetics, University of Tsukuba, Tsukuba, Japan.
Shigetoshi SanoDepartment of Dermatology, Kochi Medical School, Kochi University, Nankoku, Japan.
Hidenori InoharaDepartment of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, Suita, Japan.ORCID 0000-0003-4473-1203
Manabu FujimotoDepartment of Dermatology, University of Tsukuba, Tsukuba, Japan.ORCID 0000-0002-3062-4872
Yoshikazu InoueClinical Research Center, NHO Kinki Chuo Chest Medical Center, Sakai, Japan.ORCID 0000-0003-3994-874X
Etsuro YamaguchiDivision of Respiratory Medicine and Allergology, Department of Internal Medicine, School of Medicine, Aichi Medical University, Aichi, Japan.
Seishi OgawaDepartment of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.ORCID 0000-0002-7778-5374
Takanori KanaiDivision of Gastroenterology and Hepatology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.ORCID 0000-0002-1466-4532
Akimichi MoritaDepartment of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Fumihiko MatsudaCenter for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Mayumi TamariDivision of Molecular Genetics, Research Center for Medical Science, The Jikei University School of Medicine, Tokyo, Japan.ORCID 0000-0002-5755-9177
Atsushi KumanogohDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.ORCID 0000-0003-4749-7117
Yoshiya TanakaThe First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.ORCID 0000-0002-0807-7139
Koichiro OhmuraDepartment of Rheumatology, Kobe City Medical Center General Hospital, Kobe, Japan.
Koichi FukunagaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Seiya ImotoDivision of Health Medical Intelligence, Human Genome Center, the Institute of Medical Science, the University of Tokyo, Tokyo, Japan.ORCID 0000-0002-2989-308X
Satoru MiyanoM&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan.ORCID 0000-0002-1753-6616
Nicholas F ParrishGenome Immunobiology RIKEN Hakubi Research Team, RIKEN Center for Integrative Medical Sciences and RIKEN Cluster for Pioneering Research, Yokohama, Japan. nicholas.parrish@riken.jp.ORCID 0000-0002-6971-8016
Yukinori OkadaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan. yuki-okada@m.u-tokyo.ac.jp.ORCID 0000-0002-0311-8472
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aberrant immune responses to viral pathogens contribute to pathogenesis, but our understanding of pathological immune responses caused by viruses within the human virome, especially at a population scale, remains limited. We analyzed whole-genome sequencing datasets of 6,321 Japanese individuals, including patients with autoimmune diseases (psoriasis vulgaris, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), pulmonary alveolar proteinosis (PAP) or multiple sclerosis) and coronavirus disease 2019 (COVID-19), or healthy controls. We systematically quantified two constituents of the blood DNA virome, endogenous HHV-6 (eHHV-6) and anellovirus. Participants with eHHV-6B had higher risks of SLE and PAP; the former was validated in All of Us. eHHV-6B-positivity and high SLE disease activity index scores had strong correlations. Genome-wide association study and long-read sequencing mapped the integration of the HHV-6B genome to a locus on chromosome 22q. Epitope mapping and single-cell RNA sequencing revealed distinctive immune induction by eHHV-6B in patients with SLE. In addition, high anellovirus load correlated strongly with SLE, RA and COVID-19 status. Our analyses unveil relationships between the human virome and autoimmune and infectious diseases.
Indexed as
Autoimmune DiseasesCOVID-19DNA, ViralViromeAdultAnelloviridaeFemaleGenome-Wide Association StudyHerpesvirus 6, HumanHumansLupus Erythematosus, SystemicMaleMiddle AgedSARS-CoV-2Whole Genome SequencingDNA, Viral
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