Evidence map›Paper›PMID 39753654›Full record

ArticleScientific reports2025

Carboxymethyl hemicellulose hydrogel as a fluorescent biosensor for bacterial and fungal detection with DFT and molecular docking studies.

Hebat-Allah S Tohamy

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. RSC advances · 2025
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Hebat-Allah S TohamyCellulose and Paper Department, National Research Centre, 33 El Bohouth Str, P.O. 12622, Dokki Giza, Egypt. hebasarhan89@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new method was developed to quickly produce carboxymethyl hemicellulose (CM-Hemi) and fluorescent nitrogen-doped carbon dots (N-CDs) from sugarcane bagasse (SB). These materials were then combined with calcium chloride (CaCl₂) to create hydrogel sensors with antibacterial and antifungal properties. The CM-Hemi@Ca-N-CDs hydrogel was effective against both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria compared to CM-Hemi@Ca which give no antibacterial activity. Both hydrogels also exhibited antifungal properties against Candida albicans. Molecular docking studies revealed that the CM-Hemi@Ca-N-CDs hydrogel had strong binding interactions with the protein from Staphylococcus aureus and Candida albicans (1.92 A°) compard to Escherichia coli (2.01 A°), which was aligned with the inhibition zone measurements from the antibacterial test. The fluorescence microscope revealed differences in the emitted light color when the hydrogel interacted with different types of microorganisms, likely due to variations in their cell walls. Density functional theory (DFT) calculations indicate that the incorporation of N-CDs into the CM-Hemi@Ca hydrogel enhances its stability and rigidity. This is evidenced by the lower energy gap (E

Indexed as

Biosensing TechniquesCandida albicansHydrogelsMolecular Docking SimulationPolysaccharidesStaphylococcus aureusAnti-Bacterial AgentsAntifungal AgentsDensity Functional TheoryEscherichia coliMicrobial Sensitivity TestsAnti-Bacterial AgentsAntifungal AgentshemicelluloseHydrogelsPolysaccharidesAntibacterial activityBacterial/Fungal detectionBiosensor fluorescence cellulosic hydrogelMicrowave carboxymethyl hemicelluloseNitrogen doped carbon dots

Identifiers

PMID39753654
PMCPMC11699063

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.