Evidence map›Paper›PMID 39753628›Full record

ArticleScientific reports2025

Gastrointestinal absorption and its regulation of hawthorn leaves flavonoids.

Junwei Chow, Xiaolei Yang, Jiarong Hu, Qiuxia Yu, Yu Zhong, Xinyi Hu, Jingru Liang, Chenyang Zhu, Shiwei Yan, Longzhou Li and 5 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Junwei Chow *School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, P.R. China.
Xiaolei Yang *School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, P.R. China.
Jiarong Hu *School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, P.R. China.
Qiuxia YuSchool of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, P.R. China.
Yu ZhongSchool of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, P.R. China.
Xinyi HuSchool of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, P.R. China.
Jingru LiangSchool of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, P.R. China.
Chenyang ZhuSchool of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, P.R. China.
Shiwei YanSchool of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, P.R. China.
Longzhou LiSchool of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, P.R. China.
Haiyang LiuSchool of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, P.R. China.
Tiandian WangSchool of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, P.R. China.
Zihan WangSchool of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, P.R. China.
Long GaoSchool of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, P.R. China.
Guo MaSchool of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, P.R. China. mg0328@fudan.edu.cn.

Funding

National Natural Science Foundation of China 82074109
6 · The paper itself

Abstract

Hawthorn leave flavonoids (HLF) are widely used as an herb or dietary supplements for cardio-cerebrovascular diseases. However, its gastrointestinal absorption behavior and mechanism have not been disclosed. In this study, gastrointestinal absorption and its regulation of 4''-O-glucosylvitexin (GLV), 2''-O-rhamnosylvitexin (RHV), vitexin (VIT), rutin (RUT) and hyperoside (HP) in HLF were investigated using in vitro, in situ and in vivo models. Apparent permeability coefficient (P

Indexed as

CrataegusFlavonoidsGastrointestinal AbsorptionPlant LeavesAnimalsCaco-2 CellsHumansIntestinal AbsorptionMalePlant ExtractsRatsRats, Sprague-DawleyFlavonoidsPlant ExtractsAbsorption behaviorAbsorption mechanismHawthorn leave flavonoidsIntestinal microfloraPharmacokineticsRegulation

Identifiers

PMID39753628
PMCPMC11698746

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.