ArticleNature communications2025
Allocentric and egocentric spatial representations coexist in rodent medial entorhinal cortex.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of aged APP knock-in mice.Cell reports · 2026Article
- Coordinating Cognition: The Entorhinal Cortex in Mnemonic, Temporal and Spatial Representation.Cells · 2026Review
- Egocentric Spatial Memory Deficit in Amnestic Mild Cognitive Impairment Revealed Through Virtual Reality: Cross-Sectional Study.JMIR aging · 2026Article
- Thinking of Oneself as Someone: The Structure of Self-Representation.Cognitive science · 2026Article
- The Contribution of Spatially Tuned Brain Cells to Human Navigation Performance.KN - journal of cartography and geographic information · 2026Review
- Allocentric flocking.Nature communications · 2025Article
- A Hippocampal-Parietal Network for Reference Frame Coordination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Successful navigation relies on reciprocal transformations between spatial representations in world-centered (allocentric) and self-centered (egocentric) frames of reference. The neural basis of allocentric spatial representations has been extensively investigated with grid, border, and head-direction cells in the medial entorhinal cortex (MEC) forming key components of a 'cognitive map'. Recently, egocentric spatial representations have also been identified in several brain regions, but evidence for the coexistence of neurons encoding spatial variables in each reference frame within MEC is so far lacking. Here, we report that allocentric and egocentric spatial representations are both present in rodent MEC, with neurons in deeper layers representing the egocentric bearing and distance towards the geometric center and / or boundaries of an environment. These results demonstrate a unity of spatial coding that can guide efficient navigation and suggest that MEC may be one locus of interactions between egocentric and allocentric spatial representations in the mammalian brain.
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Registered trials
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