Evidence map›Paper›PMID 39753401›Full record

ArticleBritish journal of anaesthesia2025

Preoperative estimated glomerular filtration rate to predict cardiac events in major noncardiac surgery: a secondary analysis of two large international studies.

Pavel S Roshanov, Michael W Walsh, Amit X Garg, Meaghan Cuerden, Ngan N Lam, Ainslie M Hildebrand, Vincent W Lee, Marko Mrkobrada, Kate Leslie, Matthew T V Chan and 18 more

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00512109 completednot on this map

Vascular Events In Noncardiac Surgery Patients Cohort Evaluation (VISION) Study

TypeobservationalSponsorMcMaster UniversityRan2007 to 2014Enrolled40,060ConditionsVascular Death, Myocardial Infarction, Cardiac Arrest, Stroke
NCT01082874 phase3completednot on this map

A Large, International, Placebo-controlled, Factorial Trial to Assess the Impact of Clonidine and Acetyl-salicylic Acid (ASA) in Patients Undergoing Noncardiac Surgery Who Are at Risk of a Perioperative Cardiovascular Event

TypeinterventionalSponsorHamilton Health Sciences CorporationRan2010 to 2015Enrolled10,010ConditionsCardiovascular DiseaseArmsActive Clonidine, Placebo Clonidine, Active ASA, Placebo ASA
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Pavel S RoshanovDepartment of Medicine, Western University, London, ON, Canada; Population Health Research Institute, Hamilton, ON, Canada; Outcomes Research Consortium, Houston, TX, USA. Electronic address: proshano@uwo.ca.
Michael W WalshPopulation Health Research Institute, Hamilton, ON, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada.
Amit X GargDepartment of Medicine, Western University, London, ON, Canada.
Meaghan CuerdenLondon Health Sciences Centre, London, ON, Canada.
Ngan N LamDivision of Transplantation and Nephrology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Ainslie M HildebrandDivision of Nephrology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Vincent W LeeWestmead Applied Research Centre, Faculty of Medicine and Health, University of Sydney, NSW, Australia.
Marko MrkobradaDepartment of Medicine, Western University, London, ON, Canada.
Kate LeslieDepartment of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia.
Matthew T V ChanDepartment of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.
Flavia K BorgesDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Chew Yin WangDepartment of Anesthesiology, University of Malaya, Kuala Lumpur, Wilayah Persekutuan, Malaysia.
Denis XavierSt John's Medical College, Bangalore, Karnataka, India; Division of Clinical Research and Training, St. John's Research Institute, St. John's National Academy of Health Sciences, Bangalore, Karnataka, India.
Daniel I SesslerOutcomes Research Consortium, Department of Anesthesiology, Critical Care and Pain Medicine, University of Texas, Houston, TX, USA.
Wojciech SzczeklikCenter for Intensive Care and Perioperative Medicine, Jagiellonian University Medical College, Krakow, Małopolska, Poland.
Christian S MeyhoffDepartment of Anaesthesia and Intensive Care, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Sadeesh K SrinathanDepartment of Surgery, University of Manitoba, Winnipeg, MB, Canada.
Alben SigamaniNumen Health, Bengaluru, Karnataka, India; Carmel Research, Bengaluru, Karnataka, India.
Juan Carlos VillarCentro de Investigaciones, Fundación Cardioinfantil - Instituto de Cardiología, Bogotá, Colombia; Facultad de Ciencias de la Salud, Universidad Autónoma de Bucaramanga, Bucaramanga, Santander, Colombia.
Clara K ChowWestmead Applied Research Centre, University of Sydney, Sydney, NSW, Australia; Department of Cardiology, Westmead Hospital, Sydney, NSW, Australia.
Carísi A PolanczykGraduate Program in Epidemiology and Cardiovascular Science, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; Institute for Health Technology Assessment, Porto Alegre, Rio Grande do Sul, Brazil.
Ameen PatelDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Tyrone G HarrisonDepartment of Medicine, University of Calgary, Calgary, AB, Canada; Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada; O'Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Vikram Fielding-SinghDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Juan P CataDepartment of Anesthesiology and Perioperative Medicine, University of Texas - MD Anderson Cancer Center, Houston, TX, USA.
Joel ParlowDepartment of Anesthesiology and Perioperative Medicine, Queen's University and Kingston Health Sciences Centre, Kingston, ON, Canada.
Miriam de NadalHospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
P J DevereauxPopulation Health Research Institute, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada.

Funding

Toward optimizing dialysis in the perioperative periodK23DK138312 · NIDDK · STANFORD UNIVERSITY · PI Vikram Fielding-Singh · 2024 to 2026
$496k
American Heart Association-American Stroke Association 23CDA1053913NIDDK NIH HHS K23 DK138312
6 · The paper itself

Abstract

backgroundOptimised use of kidney function information might improve cardiac risk prediction in noncardiac surgery.

methodsIn 35,815 patients from the VISION cohort study and 9219 patients from the POISE-2 trial who were ≥45 yr old and underwent nonurgent inpatient noncardiac surgery, we examined (by age and sex) the association between continuous nonlinear preoperative estimated glomerular filtration rate (eGFR) and the composite of myocardial injury after noncardiac surgery, nonfatal cardiac arrest, or death owing to a cardiac cause within 30 days after surgery. We estimated contributions of predictive information, C-statistic, and net benefit from eGFR and other common patient and surgical characteristics to large multivariable models.

resultsThe primary composite occurred in 4725 (13.2%) patients in VISION and 1903 (20.6%) in POISE-2; in both studies cardiac events had a strong, graded association with lower preoperative eGFR that was attenuated by older age (P

conclusionsContinuous preoperative eGFR is among the best cardiac risk predictors in noncardiac surgery of the large set examined. Along with its interaction with age, preoperative eGFR would improve risk calculators. CLINICAL

trial registrationClinicalTrials.gov NCT00512109 (VISION) and NCT01082874 (POISE-2).

Indexed as

Glomerular Filtration RateHeart DiseasesPostoperative ComplicationsPreoperative CareSurgical Procedures, OperativeAgedClinical Trials, Phase III as TopicCohort StudiesFemaleHumansMaleMiddle AgedMulticenter Studies as TopicObservational Studies as TopicPredictive Value of TestsRandomized Controlled Trials as Topicchronic kidney diseasemortalityperioperative medicinerenal medicinerisk predictionsurgeryvascular events

Identifiers

PMID39753401
PMCPMC11775841

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.