ArticleJournal of photochemistry and photobiology. B, Biology2025
Photodynamic antimicrobial therapy with Erythrosin B, Eosin Y, and Rose Bengal for the inhibition of fungal keratitis isolates: An in vitro study.
Article in Journal of photochemistry and photobiology. B, Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Evaluating Photochemical Interactions Between Rose Bengal Photodynamic Antimicrobial Therapy and Topical Antifungals in Fungal Keratitis Isolates.Investigative ophthalmology & visual science · 2026Article
- Argon Laser Phototherapy as an Adjunctive Treatment for Refractory Fungal Keratitis: A Retrospective Case Series.Cureus · 2025Article
- Alternative photosensitizer penetration depth evaluation in ex vivo human eyes for photodynamic antimicrobial therapy.Therapeutic delivery · 2025Article
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Authors and funding
13 authors.
Funding
Abstract
introductionFungal keratitis is a leading cause of corneal blindness, with current antifungal treatments having limited efficacy. One promising treatment modality is Rose Bengal (RB) photodynamic antimicrobial therapy (PDAT) that has shown mixed success against fungal keratitis. Therefore, there is a need to explore the antimicrobial efficacy of other green-light activated photosensitizers that have deep penetration in the cornea to combat the deep fungal infections, such as Erythrosin B (EB) and Eosin Y (EY).
objectiveThis study will explore PDAT inhibitory effects with different photosensitizers, RB, EB, and EY against two common fungal ocular isolates, Aspergillus spp. and Fusarium spp.
methodsTwelve fungal isolates (Fusarium spp., n = 6, Aspergillus spp., n = 6) were prepared in suspension for evaluation of growth inhibition to PDAT with three photosensitizers, EB, EY, and RB. Custom green light source (λ = 518 nm, energy density = 5.4 J/cm
resultsAll twelve fungal isolates showed no inhibition to EB, EY, and RB without irradiation. Fusarium spp. were more susceptible to PDAT than Aspergillus spp. In all Fusarium solani strains, all photosensitizers with light showed full inhibition within the 47 mm diameter irradiation zone.
conclusionEB, EY, and RB PDAT demonstrated comparable antifungal inhibition against six Fusarium ocular isolates; these findings in conjunction with the deeper tissue penetration of EB and EY, are of interest to treat more advanced and deeper cases of fungal keratitis.
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