Evidence map›Paper›PMID 39752625›Full record

ArticleMedical physics2025

Grating-based x-ray dark-field mammography: Assessing complementary imaging information in simple cystic lesions and typical fibroadenoma.

Karin Hellerhoff, Wolfgang Gottwald, Kirsten Taphorn, Daniel Berthe, Michael Braun, Kai Wagner, Sandra Resch, Dominik John, Lisa Heck, Lorenz Birnbacher and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Karin HellerhoffBreast Imaging Department, Red Cross Hospital Munich, Munich, Germany.
Wolfgang GottwaldResearch Group Biomedical Imaging Physics, Department of Physics, TUM School of Natural Sciences and Munich Institute of Biomedical Engineering, Technical University of Munich, Garching, Germany.
Kirsten TaphornResearch Group Biomedical Imaging Physics, Department of Physics, TUM School of Natural Sciences and Munich Institute of Biomedical Engineering, Technical University of Munich, Garching, Germany.
Daniel BertheResearch Group Biomedical Imaging Physics, Department of Physics, TUM School of Natural Sciences and Munich Institute of Biomedical Engineering, Technical University of Munich, Garching, Germany.
Michael BraunDepartment of Gynecology, Red Cross Hospital Munich, Munich, Germany.
Kai WagnerInstitute of Pathology, Red Cross Hospital Munich, Munich, Germany.
Sandra ReschResearch Group Biomedical Imaging Physics, Department of Physics, TUM School of Natural Sciences and Munich Institute of Biomedical Engineering, Technical University of Munich, Garching, Germany.
Dominik JohnResearch Group Biomedical Imaging Physics, Department of Physics, TUM School of Natural Sciences and Munich Institute of Biomedical Engineering, Technical University of Munich, Garching, Germany.
Lisa HeckResearch Group Biomedical Imaging Physics, Department of Physics, TUM School of Natural Sciences and Munich Institute of Biomedical Engineering, Technical University of Munich, Garching, Germany.
Lorenz BirnbacherResearch Group Biomedical Imaging Physics, Department of Physics, TUM School of Natural Sciences and Munich Institute of Biomedical Engineering, Technical University of Munich, Garching, Germany.
Julia HerzenResearch Group Biomedical Imaging Physics, Department of Physics, TUM School of Natural Sciences and Munich Institute of Biomedical Engineering, Technical University of Munich, Garching, Germany.
Susanne GrandlBreast Imaging Department, Red Cross Hospital Munich, Munich, Germany.

Funding

DFG Cluster of Excellence Munich-Centre for Advanced Photonics MAP DFG EXC-158German Research Foundation DFG GRK 2274Helmholtz Research Infrastructure at Karlsruhe Institute of TechnologyKarlsruhe Nano Micro Facility
6 · The paper itself

Abstract

backgroundA significant proportion of false positive recalls of mammography-screened women is due to benign breast cysts and simple fibroadenomas. These lesions appear mammographically as smooth-shaped dense masses and require the recalling of women for a breast ultrasound to obtain complementary imaging information. They can be identified safely by ultrasound with no need for further assessment or treatment. PURPOSE: Grating-based x-ray dark-field breast imaging allows contrast formation based on both attenuation and small-angle x-ray scattering and provides complementary imaging information in one single acquisition.

methodsExperiments with ex-vivo mastectomy samples were performed with a three-grating Talbot-Lau interferometer using a laboratory-based polychromatic x-ray source. Attenuation and dark-field images were correlated to clinical mammography and complementary diagnostic imaging techniques.

resultsBenign breast lesions with homogeneous internal structures such as fibroadenomas and simple fluid-filled cysts, typically presenting as dense breast lesions in standard mammography, showed a signal drop in the dark-field image. Complicated cysts provided a higher dark-field signal.

conclusionsThe results presented show that grating-based x-ray dark-field mammography could provide complementary imaging information in one single acquisition, eliminating the need for a second examination to identify harmless cysts and simple fibroadenomas.

Indexed as

Breast CystBreast NeoplasmsFibroadenomaMammographyFemaleHumansdark‐field imaginggrating‐based interferometrymammography

Identifiers

PMID39752625
PMCPMC11972037

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.