ArticleProceedings of the National Academy of Sciences of the United States of America2025
Human brain dynamics are shaped by rare long-range connections over and above cortical geometry.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed.
- Distributed Neural Substrates for Autonomic Control During Human Thermoregulation: Brain Network Configurations of Sympathetic and Parasympathetic Innervation.Brain topography · 2026Article
- Human cortical networks trade communication efficiency for computational reliability.Science advances · 2026Article
- Modeling the influences of non-local connectomic projections on geometrically constrained cortical dynamics.PLoS computational biology · 2026Article
- Spectral organization of individualized connectome harmonics across brain structure, function and cognition.bioRxiv : the preprint server for biology · 2026Article
- Spatially structured heterogeneity shapes large-scale cortical dynamics in a model of the human cortex.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The primate claustrum as a hub for precision weighting of prediction errors across the cortical hierarchy.PLoS biology · 2026Article
- The "Brain's Traffic Map" Reveals Neural Pathways Linked to Coronary Microvascular Dysfunction in Women.Brain and behavior · 2026Observational
- Intrinsic cortical geometry is associated with individual differences in local functional organization.Research square · 2026Article
- A deformable attractor manifold organizes human resting-state brain dynamics.bioRxiv : the preprint server for biology · 2026Article
- High-resolution Bayesian Virtual Epileptic Patient using neural field models.Network neuroscience (Cambridge, Mass.) · 2026Article
- The turbulent brain: Modeling vortex interactions for understanding human cognition.Network neuroscience (Cambridge, Mass.) · 2026Article
- Benchmarking overlapping community detection methods for applications in human connectomics.Network neuroscience (Cambridge, Mass.) · 2026Article
- Human cortical dynamics reflect graded contributions of local geometry and network topography.Nature communications · 2025Article
- Cross-Species Cortical Geometry Reveals Conserved Gradients Across Primates and Human-Specific Expansion.bioRxiv : the preprint server for biology · 2025Article
- N,N-dimethyltryptamine effects on connectome harmonics, subjective experience and comparative psychedelic experiences.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Connectome harmonic decomposition tracks the presence of disconnected consciousness during ketamine-induced unresponsiveness.British journal of anaesthesia · 2025Article
- Investigating the complex cortical dynamics of an advanced concentrative absorption meditation called jhanas (ACAM-J): a geometric eigenmode analysis.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Decentralized EEG-based detection of major depressive disorder via transformer architectures and split learning.Frontiers in computational neuroscience · 2025Article
- Coming up short: Generative network models fail to accurately capture long-range connectivity.Network neuroscience (Cambridge, Mass.) · 2025Article
- Mapping the white-matter functional connectome: a personal perspective.Psychoradiology · 2025Review
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4 authors.
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Abstract
A fundamental topological principle is that the container always shapes the content. In neuroscience, this translates into how the brain anatomy shapes brain dynamics. From neuroanatomy, the topology of the mammalian brain can be approximated by local connectivity, accurately described by an exponential distance rule (EDR). The compact, folded geometry of the cortex is shaped by this local connectivity, and the geometric harmonic modes can reconstruct much of the functional dynamics. However, this ignores the fundamental role of the rare long-range (LR) cortical connections, crucial for improving information processing in the mammalian brain, but not captured by local cortical folding and geometry. Here, we show the superiority of harmonic modes combining rare LR connectivity with EDR (EDR+LR) in capturing functional dynamics (specifically LR functional connectivity and task-evoked brain activity) compared to geometry and EDR representations. Importantly, the orchestration of dynamics is carried out by a more efficient manifold made up of a low number of fundamental EDR+LR modes. Our results show the importance of rare LR connectivity for capturing the complexity of functional brain activity through a low-dimensional manifold shaped by fundamental EDR+LR modes.
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