Evidence map›Paper›PMID 39752522›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

The proteome is a terminal electron acceptor.

Avi I Flamholz, Akshit Goyal, Woodward W Fischer, Dianne K Newman, Rob Phillips

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Ecosystems as adaptive living circuits.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Avi I FlamholzDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0002-9278-5479
Akshit GoyalPhysics of Living Systems, Department of Physics, Massachusetts Institute of Technology, Cambridge MA 02139.ORCID 0000-0002-9425-8269
Woodward W FischerDivision of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0002-8836-3054
Dianne K NewmanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0003-1647-1918
Rob PhillipsDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0003-3082-2809

Funding

The Principles of Regulatory, Conformational and Evolutionary AdaptationR35GM118043 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ROB PHILLIPS · 2016 to 2026
$7.9M
Biological mechanisms and consequences of efficient extracellular electron transfer in Pseudomonas aeruginosaR01AI127850 · NIAID · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Dianne K Newman · 2017 to 2026
$5.6M
Burroughs Wellcome Fund (BWF) 1026229Gordon and Betty Moore Foundation (GBMF) GBMF4513HHS | National Institutes of Health (NIH) 1R01AI127850-01A1HHS | National Institutes of Health (NIH) 1R35 GM118043Jane Coffin Childs Memorial Fund for Medical Research (JCC) 61-1772NIAID NIH HHS R01 AI127850NIGMS NIH HHS R35 GM118043NSF | National Science Foundation Graduate Research Fellowship Program (GRFP) NSF PHY-1748958
6 · The paper itself

Abstract

Microbial metabolism is impressively flexible, enabling growth even when available nutrients differ greatly from biomass in redox state.

Indexed as

Escherichia coliOxidation-ReductionProteomeAdenosine TriphosphateBiomassCarbonElectronsElectron TransportEscherichia coli ProteinsFermentationModels, BiologicalPhotosynthesisAdenosine TriphosphateCarbonEscherichia coli ProteinsProteomeenvironmental sciencemetabolismmicrobial physiologyprotein evolutionredox chemistry

Identifiers

PMID39752522
PMCPMC11725909

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.