ArticleProceedings of the National Academy of Sciences of the United States of America2025
A mutant ASXL1-BAP1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia.
Abstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Unleashed condensation by recurrent mutations of an epigenetic regulator promotes cancer.bioRxiv : the preprint server for biology · 2026Article
- Mono-ubiquitination of histone H2A lysine 119 (H2AK119Ub): its multifaceted role in biology and implication in diseases.MedScience · 2026Review
- Article
- Prospective Analysis of Mesotheliomas in Subjects With BAP1 Cancer Syndrome: Clinical Characteristics and Epigenetic Correlates of Disease.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2025Observational
- ASXL1 mutation-related clonal hematopoiesis and age-related diseases: clinical evidence and molecular insights.International journal of hematology · 2025Review
- OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide.Nature structural & molecular biology · 2025Article
- A mutant ASXL1-BAP1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
Corrections and comments
- Update of
Authors and funding
12 authors.
Zhen Dong *Department of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037.
Hugo Sepulveda *Department of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037.
Leo J Arteaga-VazquezDepartment of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037.
Chad BlouinDepartment of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037.
Jenna FernandezDivision of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905.
Moritz BinderDivision of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905.
Wen-Chien ChouDivision of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei 10002, Taiwan.
Hwei-Fang TienDivision of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei 10002, Taiwan.
Mrinal M PatnaikDivision of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905.
Geoffrey J FaulknerMater Research Institute - University of Queensland, Woolloongabba, QLD 4102, Australia.
Samuel A MyersDepartment of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037.
Anjana RaoDepartment of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037.ORCID 0000-0002-1870-1775
Funding
The TET-DNMT-ASXL1-OGT axis: relevance to clonal hematopoiesis, heterochromatin integrity and cancerR35CA210043 · NCI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Anjana Rao · 2016 to 2026
$10.6MElucidating the signaling and protein interaction networks of the O-GlcNAc transferase during embryonic stem cell state transitionsR35GM147554 · NIGMS · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Samuel Anthony Myers · 2022 to 2026
$2.4MTargeting PLK1 in RAS mutant chronic myelomonocytic leukemiaR01CA272496 · NCI · MAYO CLINIC ROCHESTER · PI Mrinal Shiv Patnaik · 2023 to 2026
$1.7MNovaSeq5000 High Throughput SequencerS10OD025052 · OD · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI SEUMOIS, GREGORY · 2018 to 2018
$832kCyTOF Mass CytometerS10OD018499 · OD · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROTTY, SHANE P · 2014 to 2014
$802kFACSAria II Cell SorterS10RR027366 · NCRR · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROFT, MICHAEL · 2011 to 2011
$514kCalifornia Institute for Regenerative Medicine (CIRM) FellowshipDHAC | National Health and Medical Research Council (NHMRC) GNT1173711DHAC | NHMRC | National Institute for Dementia Research (NNIDR) GNT1173711HHS | NIH | National Cancer Institute (NCI) R01CA272496HHS | NIH | National Cancer Institute (NCI) R35 CA 210043HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM147554Mater Foundation (MF) unknownNCI NIH HHS R01 CA272496NCI NIH HHS R35 CA210043NCRR NIH HHS S10 RR027366NIGMS NIH HHS R35 GM147554NIH HHS S10 OD018499NIH HHS S10 OD025052NSC Taiwan MOHW109-TDU-B-211-134009NSC Taiwan NSC 112-2314-B-002-095-MY3NSC Taiwan NSC 112-2314-B-075A-004The Pew Charitable Trusts Pew Latin-American Fellows Program
Abstract
PubMed holds no abstract for this paper.
Indexed as
Clonal HematopoiesisHeterochromatinMutationRepressor ProteinsUbiquitin ThiolesteraseAnimalsDioxygenasesDNA-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA MethylationDNA Methyltransferase 3AHumansLeukemia, Myelomonocytic, ChronicMiceTumor Suppressor ProteinsASXL1 protein, humanAsxl1 protein, mouseDioxygenasesDNA-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADnmt3a protein, mouseHeterochromatinRepressor ProteinsTumor Suppressor ProteinsUbiquitin Thiolesteraseclonal hematopoiesisCMMLEHMT1/2 (GLP/G9a)heterochromatinpolycomb response-deubiquitinase (PR-DUB) complex
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.