Evidence map›Paper›PMID 39752494›Full record

ArticleScience advances2025

Transcriptional regulation of adipocyte lipolysis by IRF2BP2.

Yang Chen, Lin Liu, Ryan Calhoun, Lan Cheng, David Merrick, David J Steger, Patrick Seale

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Yang ChenInstitute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-2443-4087
Lin LiuInstitute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-9087-1146
Ryan CalhounInstitute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lan ChengInstitute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-0572-6148
David MerrickInstitute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-6464-2705
David J StegerInstitute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-1610-7024
Patrick SealeInstitute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-7119-1615

Funding

VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI DOUGLAS J EPSTEIN · 1986 to 2026
$48.3M
Functional Interrogation of T2D-associated genes in human stem cell-derived models and miceUM1DK126194 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GRANT, STRUAN F A, KAESTNER, KLAUS H · 2020 to 2024
$8.8M
Regulation of Mesenchymal Progenitor Cell Fate and Adipose Tissue RemodelingR01DK120982 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Patrick Seale · 2019 to 2026
$3.7M
Gene Networks promoting adipocyte cell differentiation and functionR01DK121801 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI SEALE, PATRICK · 2020 to 2024
$2.3M
NIDDK NIH HHS P30 DK019525NIDDK NIH HHS R01 DK120982NIDDK NIH HHS R01 DK121801NIDDK NIH HHS UM1 DK126194
6 · The paper itself

Abstract

Adipocyte lipolysis controls systemic energy levels and metabolic homeostasis. Lipolysis is regulated by posttranslational modifications of key lipolytic enzymes. However, less is known about the transcriptional mechanisms that regulate lipolysis. Here, we identify interferon regulatory factor-2 binding protein 2 (IRF2BP2) as a transcriptional repressor of adipocyte lipolysis. Deletion of

Indexed as

AdipocytesGene Expression RegulationLipolysisAnimalsDNA-Binding ProteinsHumansMiceMice, KnockoutSterol EsteraseTranscription FactorsTranscription, GeneticDNA-Binding ProteinsIRF2BP2 protein, humanIRF2BP2 protein, mouseSterol EsteraseTranscription Factors

Identifiers

PMID39752494
PMCPMC11698119

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.