Evidence map›Paper›PMID 39752486›Full record

ArticleScience advances2025

Its own architect: Flipping cardiolipin synthase.

Katsuhiro Sawasato, William Dowhan, Mikhail Bogdanov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Dark Side ofJournal of the American Chemical Society · 2026
    Article
  3. A surface-exposed cardiolipin synthase provides an unexpected paradigm for maintaining the Gram-negative outer membrane.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Katsuhiro SawasatoDepartment of Biochemistry and Molecular Biology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.ORCID 0000-0001-9965-970X
William DowhanDepartment of Biochemistry and Molecular Biology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.ORCID 0000-0002-7252-3607
Mikhail BogdanovDepartment of Biochemistry and Molecular Biology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.ORCID 0000-0002-7176-8127

Funding

Protein sequence determinants and properties of the lipid bilayer that govern membrane protein dynamic organizationR01GM121493 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOGDANOV, MIKHAIL V., DOWHAN, WILLIAM · 2017 to 2025
$3.6M
NIGMS NIH HHS R01 GM121493
6 · The paper itself

Abstract

Current dogma assumes that lipid asymmetry in biological membranes is actively maintained and dispensable for cell viability. The inner (cytoplasmic) membrane (IM) of

Indexed as

CardiolipinsCell MembraneEscherichia coliMembrane ProteinsTransferases (Other Substituted Phosphate Groups)Escherichia coli ProteinsMutationPhosphatidylethanolaminesCardiolipinscardiolipin synthetaseEscherichia coli ProteinsMembrane ProteinsphosphatidylethanolaminePhosphatidylethanolaminesTransferases (Other Substituted Phosphate Groups)

Identifiers

PMID39752486
PMCPMC11698083

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.