ArticleACS nano2025
Genetically Engineered, Multichromophore Virus-Like Nanoparticles with Ultranarrow Distribution of Emission Intensity.
Irina B Tsvetkova, Nora Roos, Lohra M Miller, Nadia DiNunno, Marcel Conrady, Domenic Ebert, Hauke Lilie, Liam W Scott, Martin F Jarrold, Joseph Che-Yen Wang and 2 more
Abstract read
In one paragraphArticle in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Irina B TsvetkovaDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.ORCID 0000-0002-3433-328X Nora RoosUniversity Hospital Tuebingen, Institute for Medical Virology and Epidemiology of Viral Diseases, Elfriede Aulhorn-Str. 06, Tuebingen 72076, Germany.
Lohra M MillerDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.
Nadia DiNunnoDepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States.
Marcel ConradyUniversity Hospital Tuebingen, Institute for Medical Virology and Epidemiology of Viral Diseases, Elfriede Aulhorn-Str. 06, Tuebingen 72076, Germany.
Domenic EbertUniversity Hospital Tuebingen, Institute for Medical Virology and Epidemiology of Viral Diseases, Elfriede Aulhorn-Str. 06, Tuebingen 72076, Germany.ORCID 0000-0002-1712-9543 Hauke LilieInstitute for Biotechnology and Biochemistry/Technical Biochemistry, Martin-Luther-University Halle-Wittemberg, Halle 06120, Germany.
Martin F JarroldDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.ORCID 0000-0001-7084-176X Joseph Che-Yen WangDepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States.ORCID 0000-0001-6580-3531 Claudia SimonUniversity Hospital Tuebingen, Institute for Medical Virology and Epidemiology of Viral Diseases, Elfriede Aulhorn-Str. 06, Tuebingen 72076, Germany.
Bogdan DragneaDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.ORCID 0000-0003-0611-2006 Funding
Structural characterization of native HBV capsids and virions from human cellsR01AI173104 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Joseph Che-Yen Wang · 2023 to 2026
$2.8MGraduate Training Program in Quantitative and Chemical Biology at Indiana University BloomingtonT32GM131994 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI JARED C LEWIS · 2019 to 2026
$2.4MDissecting Structural Details of Hepadnavirus Subviral ParticlesR21AI164119 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI WANG, CHE-YEN · 2021 to 2022
$446kNIAID NIH HHS R01 AI173104NIAID NIH HHS R21 AI164119NIGMS NIH HHS T32 GM131994
6 · The paper itselfAbstract
Variance in the properties of optical mesoscopic probes is often a limiting factor in applications. In the thermodynamic limit, the smaller the probe, the larger the relative variance. However, specific viral protein cages can assemble efficiently outside the bounds of statistical fluctuations at equilibrium through a process that is characterized by intrinsic quality-control and self-limiting capabilities. In this paper, an approach is described that leverages stoichiometric and structural accuracy in the murine polyoma virus capsid assembly to demonstrate bright, narrowly distributed fluorescence intensity from multichromophore particles that surpass state-of-the-art fluorescent nanosphere probes. Charge-detection mass spectrometry analysis demonstrated that proteins resulting from the fusion of superfolding green fluorescent protein (sfGFP) murine polyoma virus coat proteins self-assemble
Indexed as
Capsid ProteinsGenetic EngineeringNanoparticlesPolyomavirusAnimalsCapsidGreen Fluorescent ProteinsMiceCapsid ProteinsGreen Fluorescent Proteinsbright fluorescent probesfluorescent protein fusionfluorescent virus-like particlesmurine polyoma virusnanoflow cytometryvirus nanotechnology
Identifiers
PMID39752260
PMCPMC11974147
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