Evidence map›Paper›PMID 39752024›Full record

Observational studyJapanese journal of ophthalmology2025

Incidence of corneal perforation and lagophthalmos in patients with leprosy in Japan based on 40-year observations.

Takashi Ono, Takuya Iwasaki, Keita Takada, Shota Tokuda, Toshihiro Sakisaka, Yosai Mori, Ryohei Nejima, Masao Kakibuchi, Takashi Miyai, Kazunori Miyata

Abstract readObservational Study
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In one paragraph

Observational study in Japanese journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Takashi OnoMiyata Eye Hospital, 6-3, Kuraharacho, Miyakonojo, 885-0051, Miyazaki, Japan. taono-tky@umin.ac.jp.ORCID http://orcid.org/0000-0002-1288-2798
Takuya IwasakiMiyata Eye Hospital, 6-3, Kuraharacho, Miyakonojo, 885-0051, Miyazaki, Japan.
Keita TakadaMiyata Eye Hospital, 6-3, Kuraharacho, Miyakonojo, 885-0051, Miyazaki, Japan.
Shota TokudaMiyata Eye Hospital, 6-3, Kuraharacho, Miyakonojo, 885-0051, Miyazaki, Japan.
Toshihiro SakisakaMiyata Eye Hospital, 6-3, Kuraharacho, Miyakonojo, 885-0051, Miyazaki, Japan.
Yosai MoriMiyata Eye Hospital, 6-3, Kuraharacho, Miyakonojo, 885-0051, Miyazaki, Japan.
Ryohei NejimaMiyata Eye Hospital, 6-3, Kuraharacho, Miyakonojo, 885-0051, Miyazaki, Japan.
Masao KakibuchiDepartment of Plastic Surgery, Hyogo Medical University, Nishinomiya, Japan.
Takashi MiyaiDepartment of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kazunori MiyataMiyata Eye Hospital, 6-3, Kuraharacho, Miyakonojo, 885-0051, Miyazaki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to report the incidence, characteristics, and prognosis of corneal perforation in patients with leprosy. STUDY

designRetrospective observational study.

methodsPatients who presented with leprosy and visited a specialised ophthalmology hospital (Miyata Eye Hospital, Miyazaki, Japan) between 1980 and 2020 were included. Their medical charts were retrospectively reviewed, and the incidence of lagophthalmos and corneal perforation was examined. Additionally, the presentation, treatment, and prognosis of patients with corneal perforations were assessed.

resultsIn total, the records of 472 eyes of 236 patients (128 men and 108 women; mean age, 81.2 ± 7.5 years) diagnosed with leprosy were reviewed. Forty-one patients were diagnosed with lagophthalmos, and two of these patients (4.8%) showed signs of corneal perforation. Patients with lagophthalmos presented significantly more frequently with cicatricial contraction of eyelids (p < 0.001), superficial punctate keratopathy (p < 0.001), epithelial defect (p = 0.039), and corneal ulcer (p < 0.001) compared with patients without lagophthalmos. Patients with corneal perforation had uveitis more frequently compared with those without corneal perforation (p = 0.01).

conclusionPatients with leprosy frequently develop lagophthalmos. Patients with uveitis associated with leprosy are especially at risk of corneal perforation.

Indexed as

Corneal PerforationEyelid DiseasesLeprosyAgedAged, 80 and overFemaleFollow-Up StudiesHumansIncidenceJapanLagophthalmosMaleMiddle AgedPrognosisRetrospective StudiesTime FactorsCorneal nerve palsyCorneal transplantationLamellar corneal transplantationNeurotrophic keratopathy

Identifiers

PMID39752024

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.