Evidence map›Paper›PMID 39751989›Full record

Observational studyAging clinical and experimental research2025

Associations between frailty and cognitive impairment in Parkinson´s disease: a cross-sectional study.

M C Sousa-Fraguas, G Rodríguez-Fuentes, D Lastra-Barreira, N M Conejo

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05388526 (Relationship Between Frailty and Cognitive Impairment in Patients With Parkinson's Disease or Secondary Parkinsonism.), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05388526 completednot on this map

Relationship Between Frailty and Cognitive Impairment in Patients With Parkinson's Disease or Secondary Parkinsonism.

TypeobservationalSponsorUniversity of OviedoRan2022 to 2023Enrolled100ConditionsParkinson DiseaseArmsNo intervention
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Frailty in Parkinson's disease: time to integrate it into treatment decision-making?Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

M C Sousa-FraguasDepartment of Surgery and Medical-Surgical Specialties, Faculty of Medicine and Health Sciences, University of Oviedo, Oviedo, 33006, Spain. sousamaria@uniovi.es.ORCID https://orcid.org/0000-0001-8255-9454
G Rodríguez-FuentesDepartment of Functional Biology and Health Sciences, Faculty of Physiotherapy, Universidade de Vigo, Pontevedra, 36005, Spain.ORCID https://orcid.org/0000-0003-2720-1497
D Lastra-BarreiraJove Hospital Foundation, Gijón, 33290, Spain.ORCID https://orcid.org/0000-0001-9713-3018
N M ConejoInstituto de Neurociencias del Principado de Asturias (INEUROPA), University of Oviedo, Oviedo, 33003, Spain.ORCID https://orcid.org/0000-0003-4749-5453

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe presence of frailty is common in people with Parkinson's disease, as is cognitive dysfunction. Previous research on frailty has focused on the physical aspects of the pathology.

aimsTo analyze the relationship between frailty and cognitive impairment in patients with Parkinson's disease and to know which disease characteristics are associated with frailty.

methodsAn observational, correlational and cross-sectional study was conducted. Participants were recruited from a Home Rehabilitation Service and two Parkinson's Associations. An individualized assessment was carried out by means of a structured interview. Frailty was assessed with the Fried scale and cognitive function with the Mini Mental State Examination and the Parkinson's Disease Cognitive Rating Scale.

results90 patients were recruited, 60% men, with a mean age of 73.50 (6.71) years. Frailty was associated with age and disease severity (p < 0.05). Frail patients presented worse cognitive performance relative to pre-frail and robust patients. A negative correlation (coefficient - 0.503) was observed between frailty and measures of patients' cognitive function (p < 0.05). DISCUSSION: The coexistence of frailty and cognitive impairment should be assessed, as PD patients with both conditions are more vulnerable and have a higher chance of experiencing adverse effects.

conclusionFrail patients with Parkinson's disease present an impairment of cognitive functions dependent on cortical and subcortical regions, being these regions more preserved in the case of robust. The development of programs for early detection of frailty and cognitive function in these patients is necessary to implement strategic intervention plans focused on reversing frailty and cognitive impairment. PROTOCOL REGISTRATION NUMBER: http://www. CLINICALTRIALS: gov ID: NCT05388526.

Indexed as

Cognitive DysfunctionFrailtyParkinson DiseaseAgedAged, 80 and overCognitionCross-Sectional StudiesFemaleFrail ElderlyHumansMaleMiddle AgedAssociationCognitive dysfunctionFrailtyParkinson´s disease

Identifiers

PMID39751989
PMCPMC11698760

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.