Evidence map›Paper›PMID 39751986›Full record

ArticleSleep & breathing = Schlaf & Atmung2025

Relationship between REI and PSA in patients with obstructive sleep apnea: a prospective case-control study.

Lijuan Yang, Ying Feng, Jianhua Xue, Jianguang Tian, Yunle Wang

Abstract read
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In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lijuan Yang *Clinical Internal Medicine Department, Shanghai Health and Medical Center, Wuxi, 214065, People's Republic of China.
Ying Feng *Clinical Internal Medicine Department, Shanghai Health and Medical Center, Wuxi, 214065, People's Republic of China.
Jianhua XueScience and Education Department, Shanghai Health and Medical Center, Wuxi, China.
Jianguang TianScience and Education Department, Shanghai Health and Medical Center, Wuxi, China.
Yunle WangClinical Internal Medicine Department, Shanghai Health and Medical Center, Wuxi, 214065, People's Republic of China. echo1213@yeah.net.ORCID 0009-0001-6792-2312

Funding

Health and Family Planning Commission of Sichuan Province GWVI-8Science and Technology Service Network Plan 2022YFC3600903State Key Laboratory of Drug Research, Chinese Academy of Sciences SHWSRS(2023)_062
6 · The paper itself

Abstract

backgroundObstructive sleep apnea has been associated with various urinary system diseases, including prostatic hyperplasia and nocturia. Recently, it has been linked to prostate cancer. This study investigated the relationship between the apnea hypopnea index, prostate-specific antigen (PSA) levels, and changes in PSA.

methodsA total of 673 male patients who received portable sleep monitoring were assessed. All participants underwent thorough health assessments, including PSA testing. Individuals in Study 1 were divided into OSA and control groups based on an REI (Respiratory event index) ≥ 15 events/h. In Study 2, 176participants from the initial study were retested for PSA after three years.

resultsIn Study 1, patients with OSA had significantly higher ln-transformed PSA levels than controls (P < 0.05). Ln-transformed PSA levels showed a positive correlation with the REI (r = 0.184, p = 0.015). In Study 2, after three years, the ln-transformed PSA level increased by 0.13 ng/ml in the OSA group, while it decreased by -0.05 ng/ml in the control group. The change in ln-transformed PSA was significantly higher in patients with OSA (p = 0.014). Even after adjusting for age, body mass index (BMI), smoking, hypertension, and diabetes, REI remained a significant predictor of PSA level changes (β = 0.226, 95% CI = 0.001-0.009; p = 0.008).

conclusionsThis study highlights the close relationship between REI and PSA levels in individuals with obstructive sleep apnea, indicating that REI is an independent risk factor for PSA levels. Obstructive sleep apnea may be associated with the incidence of prostate cancer.

Indexed as

Prostate-Specific AntigenSleep Apnea, ObstructiveAdultAgedCase-Control StudiesHumansMaleMiddle AgedPolysomnographyProspective StudiesProstatic NeoplasmsRisk FactorsProstate-Specific AntigenObstructive sleep apneaProstate cancerProstate-specific antigenRespiratory event indexUrinary system diseases

Identifiers

PMID39751986

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.