Evidence map›Paper›PMID 39751976›Full record

Observational studyClinical rheumatology2025

Discriminative features of immunoglobulin G4-related disease (IgG4-RD) and associated autoimmune rheumatic diseases (ARDs) in a nationwide observational cohort: study from the Egyptian College of Rheumatology.

Hany El-Saadany, Hanan El-Saadany, Samar Tharwat, Wael Soliman, Shereen El Shereef, Abdelazeim Elhefny, Ahmed Yehia, Emad El-Shebini, Noha Khalil, Aya El-Hindawy and 6 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hany El-SaadanyInternal Medicine and Rheumatology Department, Armed Forces College of Medicine, Cairo, Egypt.
Hanan El-SaadanyRheumatology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Samar TharwatRheumatology and Immunology Unit, Internal Medicine Department, Mansoura University, Mansoura, Egypt. samartharwat2000@mans.edu.eg.ORCID http://orcid.org/0000-0001-9892-2449
Wael SolimanTropical Medicine Department, Faculty of Medicine, Minia University, Minia, Egypt.
Shereen El ShereefRheumatology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Abdelazeim ElhefnyInternal Medicine and Rheumatology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ahmed YehiaInternal Medicine and Rheumatology Department, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt.
Emad El-ShebiniInternal Medicine and Rheumatology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt.
Noha KhalilInternal Medicine and Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Aya El-HindawyRheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Nevin HammamRheumatology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Ahmed El-SamanRheumatology Department, Faculty of Medicine, Sohag University, Sohag, Egypt.
Fatma AliRheumatology Department, Faculty of Medicine, Minia University, Minia, Egypt.
Shereen ElwanRheumatology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Tamer A GheitaRheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Egyptian College of Rheumatology IgG4 Study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of this study is to present the clinical characteristics of immunoglobulin G4-related diseases (IgG4-RD) patients and describe associated overlap with autoimmune rheumatic diseases (ARDs). PATIENTS AND

methodsThis cross-sectional study included 81 patients with IgG4-RD who were recruited from 13 specialized rheumatology departments and centers across the country in collaboration with the Egyptian College of Rheumatology (ECR). Patients underwent a thorough history-taking and clinical examination. We reviewed patients' medical records and recorded the medications they used. The presence of comorbidities or cumulative manifestations was determined. Laboratory investigations, imaging, and biopsy histopathology were assessed.

resultsThe mean (SD) age was 41.4 (14.6) years with 60 females and 21 males (F/M 2.9:1). The diagnosis was definite in 50 (61.7%), probable in 19 (23.5%), and possible in 12 (14.8%). The most common cumulative clinical features are IgG4-related respiratory disease in 19 (23.5%), autoimmune pancreatitis (AIP) in 18 (22.2%), and Riedel's thyroiditis in 17 (21.0%). Approximately 80% were administered corticosteroids, whereas 40% received azathioprine as adjunct therapy. Approximately 16% developed a relapse with this combination and transitioned to an alternative steroid-sparing treatment. Twelve individuals (14.7%) required rituximab. Fifty percent of patients receiving rituximab (six patients) exhibited complete improvement, while the remaining had partial improvement. Ten (12.3%) patients had associated ARDs: five (6.2%) with systemic lupus erythematosus (SLE), four (4.9%) with rheumatoid arthritis (RA), and one with vasculitis. Of the four patients with associated RA, three were rheumatoid factor (RF) negative. IgG4 was in all cases, RF was positive in 18.5%, and antinuclear antibody was in 14.7%.

conclusionIgG4-RDs exhibit a wide range of presentations, closely associated with ARDs. Awareness among clinicians about this condition will increase their consideration and rate of prompt diagnosis, which is essential to prevent damage to critical organs. Key Points • IgG4-RDs have a myriad spectrum of presentation with a close link to rheumatic diseases. • Awareness among clinicians about this condition will increase their consideration and rate of prompt diagnosis. • The lack of reliable biomarkers for this condition has been an important hurdle for diagnosis.

Indexed as

Autoimmune DiseasesImmunoglobulin G4-Related DiseaseRheumatic DiseasesAdultCross-Sectional StudiesEgyptFemaleHumansImmunoglobulin GMaleMiddle AgedImmunoglobulin GAutoimmune rheumatic diseasesImmunoglobulin G4-related disease (IgG4-RD)Rheumatological dilemma

Identifiers

PMID39751976
PMCPMC11775065

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.