Evidence map›Paper›PMID 39751686›Full record

ArticleCalcified tissue international2025

Helicobacter pylori-Related Chronic Gastritis as a Risk Factor for Lower Bone Mineral Density.

Izumi Inoue, Noriko Yoshimura, Toshiko Iidaka, Chiaki Horii, Shigeyuki Muraki, Hiroyuki Oka, Hiroshi Kawaguchi, Toru Akune, Takao Maekita, Kanae Mure and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Calcified tissue international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Izumi InoueHealth Service Center, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-Ku, Tokyo, 108-8477, Japan. iinoue0@kaiyodai.ac.jp.ORCID 0000-0002-8121-0127
Noriko YoshimuraDepartment of Prevention Medicine for Locomotive Organ Disorders, 22, Century Medical and Research Center, The University of Tokyo, Tokyo, 113-8655, Japan.
Toshiko IidakaDepartment of Prevention Medicine for Locomotive Organ Disorders, 22, Century Medical and Research Center, The University of Tokyo, Tokyo, 113-8655, Japan.
Chiaki HoriiDepartment of Orthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.
Shigeyuki MurakiDepartment of Prevention Medicine for Locomotive Organ Disorders, 22, Century Medical and Research Center, The University of Tokyo, Tokyo, 113-8655, Japan.
Hiroyuki OkaDepartment of Medical Research and Management for Musculoskeletal Pain, 22, Century Medical and Research Center, The University of Tokyo, Tokyo, 113-8655, Japan.
Hiroshi KawaguchiTokyo Neurological Center, Tokyo, 105-0001, Japan.
Toru AkuneNational Rehabilitation Center for Persons with Disabilities, Saitama, 359-0042, Japan.
Takao MaekitaDepartment of Gastroenterology, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Wakayama, 641-0012, Japan.
Kanae MureDepartment of Public Health, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Wakayama, 641-0012, Japan.
Kozo NakamuraTowa Hospital, Tokyo, 120-0003, Japan.
Sakae TanakaDepartment of Orthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.
Satoshi MochidaDepartment of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical University, Saitama, 350-0495, Japan.
Masao IchinoseDepartment of Gastroenterology, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Wakayama, 641-0012, Japan.

Funding

Japan Society for the Promotion of Science 18K10063Japan Society for the Promotion of Science 22K10552
6 · The paper itself

Abstract

We evaluated the role of Helicobacter pylori (H. pylori)-related chronic gastritis in the development of osteoporosis in a population-based study. A total of 1690 subjects in the cohort of the Research on Osteoarthritis/ osteoporosis Against Disability (ROAD) were investigated, and the association between gastritis and osteoporosis was evaluated by the presence of serologically assessed H. pylori-related chronic gastritis and its stage, based on H. pylori antibody titer and pepsinogen. The presence of the gastritis was associated with significantly lower bone mineral density (BMD) assessed by dual-energy x-ray absorptiometry and a significant risk of lower BMD was observed in femoral neck (adjusted odds ratio [OR]: 0.78, 95% confidence interval [CI]: 061-0.99). The progression of the gastritis appeared to further increase the risk. In the stage of non-atrophic gastritis, the risk of lower BMD was significantly high, especially in a subgroup with higher gastritis activity in the femoral neck (adjusted OR: 0.61, 95% CI: 0.42-0.89). Meanwhile, in the stage of atrophic gastritis, the highest and significant risk of lower BMD was observed in a subgroup with the most extensive and severe atrophy in femoral neck (adjusted OR: 0.62, 95% CI: 0.42-0.91). These results suggest that H. pylori-related chronic gastritis is involved in the risk of osteoporosis, with higher activity of gastritis and more extensive atrophy leading to further increased risk. The serologically assessed stage of the gastritis could be used to identify a high-risk group for osteoporosis in H. pylori-infected subjects from general population.

Indexed as

Bone DensityGastritisHelicobacter InfectionsHelicobacter pyloriOsteoporosisAbsorptiometry, PhotonAdultAgedChronic DiseaseCohort StudiesFemaleFemur NeckHumansMaleMiddle AgedRisk FactorsAtrophic gastritisBone mineral densityHelicobacter pyloriPepsinogenPopulation-based study

Identifiers

PMID39751686
PMCPMC11698759

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.