Evidence map›Paper›PMID 39751179›Full record

ArticleThe Journal of experimental medicine2025

Tissue-resident NK cells do their own glandscaping.

Jacob A Myers, Shanelle P Reilly, Laurent Brossay

Abstract read
In one paragraph

Article in The Journal of experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cell-free secretome of CD56Theranostics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jacob A MyersDivision of Biology and Medicine, Department of Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.ORCID 0000-0002-4166-2356
Shanelle P ReillyDivision of Biology and Medicine, Department of Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.ORCID 0000-0001-9465-706X
Laurent BrossayDivision of Biology and Medicine, Department of Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.ORCID 0000-0002-7497-8488

Funding

NK T Cell Interactions with NK Cells During Viral InfectionR01AI046709 · NIAID · BROWN UNIVERSITY · PI BROSSAY, LAURENT · 2001 to 2022
$8.0M
Brown Respiratory Research Training ProgramT32HL134625 · NHLBI · BROWN UNIVERSITY · PI Elizabeth O Harrington, Sharon Irene Smith Rounds · 2017 to 2026
$5.1M
Immune response to MCMV infection in the salivary glandsR01AI173163 · NIAID · BROWN UNIVERSITY · PI Laurent Brossay · 2023 to 2026
$3.2M
Short-Term Training Program to Increase Diversity in Health-Related ResearchR25HL088992 · NHLBI · BROWN UNIVERSITY · PI ABID, RUHUL, DIAZ, JOSEPH A · 2007 to 2024
$1.9M
NHLBI NIH HHS R25 HL088992NHLBI NIH HHS T32 HL134625NIAID NIH HHS R01 AI046709NIAID NIH HHS R01 AI173163NIH HHS R01AI046709
6 · The paper itself

Abstract

In this issue of JEM, Sparano et al. (https://doi.org/10.1084/jem.20240930) present compelling evidence that salivary gland trNK cells originate from cNK cells and are developmentally distinct from ILC1 cells. Mechanistically, they demonstrate that continuous autocrine TGF-β signaling drives salivary gland tissue residency and works in synergy with IL-15 to enhance Hobit-dependent cytotoxicity.

Indexed as

Interleukin-15Killer Cells, NaturalSalivary GlandsTransforming Growth Factor betaAnimalsHumansSignal TransductionInterleukin-15Transforming Growth Factor beta

Identifiers

PMID39751179
PMCPMC11697971

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.