Versatile Stimuli-Responsive Controlled Release of Pinanediol-Caged Boronic Esters for Spatiotemporal and Nitroreductase-Selective Glucose Bioimaging.

Chih-Yao Kao, Ying-Wei Chen, Yu-Cheng Liu, Jen-Hsuan Wei, Tsung-Shing Andrew Wang

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Article in ACS sensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Chih-Yao KaoDepartment of Chemistry and Center for Emerging Material and Advanced Devices, National Taiwan University, Taipei 106319, Taiwan (R.O.C.).ORCID 0009-0008-2467-2123

Ying-Wei ChenDepartment of Chemistry and Center for Emerging Material and Advanced Devices, National Taiwan University, Taipei 106319, Taiwan (R.O.C.).

Yu-Cheng LiuInstitute of Molecular Biology, Academia Sinica, Nankang, Taipei 115201, Taiwan (R.O.C.).

Jen-Hsuan WeiInstitute of Molecular Biology, Academia Sinica, Nankang, Taipei 115201, Taiwan (R.O.C.).

Tsung-Shing Andrew WangDepartment of Chemistry and Center for Emerging Material and Advanced Devices, National Taiwan University, Taipei 106319, Taiwan (R.O.C.).ORCID 0000-0002-4690-3438

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Boronic acids have been widely applied in various biological fields, particularly achieving significant practical progress in boronic acid-based glucose sensing. However, boronic acids exhibit nonspecific binding to other nucleophiles, and the inherent lability of boronic esters in biological systems limits their further applications. Herein, we developed a stimuli-responsive controllable caging strategy to achieve photoresponsive spatiotemporally and nitroreductase-responsive cancer cell-selective glucose sensing. We introduced

Indexed as

Biosensing TechniquesBoronic AcidsEstersGlucoseNitroreductasesHumansOptical ImagingBoronic AcidsEstersGlucoseNitroreductasesboronic acidsglucose sensingpinanediolself-immolativestimuli-responsive

Identifiers

PMID39750141

DOI10.1021/acssensors.4c02811

PMCPMC11773560

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.