Evidence map›Paper›PMID 39749708›Full record

ArticleInternational journal of oncology2025

LGR4 promotes proliferation and homing via activation of the NF‑κB signaling pathway in multiple myeloma.

Nihan He, Qin Yang, Zhengjiang Li, Jiaojiao Guo, Chunmei Kuang, Yinghong Zhu, Xing Liu, Xun Chen, Fangming Shi, Xiangling Feng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nihan HeNational Clinical Research Center for Geriatric Disorders, Key Laboratory for Carcinogenesis and Invasion, Chinese Ministry of Education, Furong Laboratory, Changsha, Hunan 410008, P.R. China.
Qin YangDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Zhengjiang LiNational Clinical Research Center for Geriatric Disorders, Key Laboratory for Carcinogenesis and Invasion, Chinese Ministry of Education, Furong Laboratory, Changsha, Hunan 410008, P.R. China.
Jiaojiao GuoDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Chunmei KuangDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Yinghong ZhuNational Clinical Research Center for Geriatric Disorders, Key Laboratory for Carcinogenesis and Invasion, Chinese Ministry of Education, Furong Laboratory, Changsha, Hunan 410008, P.R. China.
Xing LiuNational Clinical Research Center for Geriatric Disorders, Key Laboratory for Carcinogenesis and Invasion, Chinese Ministry of Education, Furong Laboratory, Changsha, Hunan 410008, P.R. China.
Xun ChenNational Clinical Research Center for Geriatric Disorders, Key Laboratory for Carcinogenesis and Invasion, Chinese Ministry of Education, Furong Laboratory, Changsha, Hunan 410008, P.R. China.
Fangming ShiNational Clinical Research Center for Geriatric Disorders, Key Laboratory for Carcinogenesis and Invasion, Chinese Ministry of Education, Furong Laboratory, Changsha, Hunan 410008, P.R. China.
Xiangling FengXiangya School of Public Health, Central South University, Changsha, Hunan 410006, P.R. China.
Gang AnState Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 300074, P.R. China.
Guoping ZhangDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Wen ZhouNational Clinical Research Center for Geriatric Disorders, Key Laboratory for Carcinogenesis and Invasion, Chinese Ministry of Education, Furong Laboratory, Changsha, Hunan 410008, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple myeloma (MM) is a plasma cell malignancy characterized by clonal proliferation in the bone marrow (BM). Previously, it was reported that G‑protein‑coupled receptor 4 (LGR4) contributed to early hematopoiesis and was associated with poor prognosis in patients with MM. However, the mechanism of cell homing and migration, which is critical for MM progression, remains unclear. In the present study, cell counting, cell cycle and BrdU assays were performed to evaluate cell proliferation. Transwell assay and Xenograft mouse models were performed to evaluate cell migration and homing ability both

Indexed as

Cell MovementCell ProliferationMultiple MyelomaNF-kappa BReceptors, G-Protein-CoupledSignal TransductionAnimalsCell AdhesionCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMaleMiceXenograft Model Antitumor AssaysLGR4 protein, humanNF-kappa BReceptors, G-Protein-Coupledcell homingLGR4multiple myeloma

Identifiers

PMID39749708
PMCPMC11753772

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.