ArticleFrontiers in aging neuroscience2024
Cardiorespiratory fitness, hippocampal subfield morphology, and episodic memory in older adults.
Article in Frontiers in aging neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02875301 (Investigating Gains in Neurocognition in an Intervention Trial of Exercise), which is not on this map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating Gains in Neurocognition in an Intervention Trial of Exercise
Who cites it
4 citing papers in PubMed.
- Exploring the relative contributions of multiple modifiable physical health variables to executive function and episodic memory performance in older adults.Neuropsychology · 2026Article
- Physical Activity Is Associated With Age-Related Differences in Hippocampal Macrostructure and Microstructure in Middle-Aged and Older Adults.Hippocampus · 2026Article
- Association between 24-h time-use composition and brain age: The IGNITE study.Alzheimer's & dementia (New York, N. Y.)Article
- White matter microstructure mediates the association between cardiorespiratory fitness and cognitive performance in older adults.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
Objective: Age-related hippocampal atrophy is associated with memory loss in older adults, and certain hippocampal subfields are more vulnerable to age-related atrophy than others. Cardiorespiratory fitness (CRF) may be an important protective factor for preserving hippocampal volume, but little is known about how CRF relates to the volume of specific hippocampal subfields, and whether associations between CRF and hippocampal subfield volumes are related to episodic memory performance. To address these gaps, the current study evaluates the associations among baseline CRF, hippocampal subfield volumes, and episodic memory performance in cognitively unimpaired older adults from the Investigating Gains in Neurocognition Trial of Exercise (IGNITE) (NCT02875301). Methods: Participants ( Results: Higher CRF was significantly associated with greater total left ( Discussion: While higher CRF was significantly associated with greater total hippocampal volume, CRF was not associated with all underlying subfield volumes. Our results further demonstrate the relevance of the associations between CRF and hippocampal volume for episodic memory performance. Finally, our results suggest that the regionally-specific effects of aging and Alzheimer's disease on hippocampal subfields could be mitigated by maintaining higher CRF in older adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.