ReviewDermatology reports2024
Isotretinoin musculoskeletahl side effects: a systematic review.
Review in Dermatology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- The Bacterial Landscape of Facial Skin: From Homeostasis to Skin Conditions.Dermatology and therapy · 2026Review
- Comparative radiologic characteristics of isotretinoin-induced sacroiliitis and axial spondyloarthritis.Irish journal of medical science · 2026Article
- SAPHO Syndrome Presenting With Severe Inflammatory Back Pain (Sacroiliitis) and Rare Retinol Associated Myopathy in an Iraqi Adolescent Male: A Case Report and Literature Review.Clinical case reports · 2026Article
- Divergent System Organ Class Safety Profiles of Isotretinoin Versus Topical Retinoids: An EudraVigilance Disproportionality Analysis.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Genetics and pathophysiology of diffuse idiopathic skeletal hyperostosis.Frontiers in endocrinology · 2026Review
- Sex- and age-specific musculoskeletal adverse events of isotretinoin: disproportionality analysis of the FAERS database combined with a clinical case series.Frontiers in pharmacology · 2026Article
- Isotretinoin-Associated Myopathy With Normal Creatine Kinase (CK) Levels: EMG-Based Diagnosis at Low Dose-A Case Report.Clinical case reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to investigate musculoskeletal complications secondary to isotretinoin use. A systematic review was conducted, and a total of 49 studies, including analytical studies, case reports, and case series, were included in the analysis. The studies examined musculoskeletal symptoms, diagnostic findings, and treatment approaches associated with isotretinoin use. Musculoskeletal symptoms reported in the studies included lethargy, myalgia, low back pain, arthralgia, tendinopathy, and sacroiliitis. Physical examination findings and radiological findings were used to confirm the diagnoses. Treatment approaches ranged from [non-steroidal anti-inflammatory drugs (NSAIDs)] to discontinuation of isotretinoin. Some studies have explored the impact of isotretinoin dosage, treatment duration, and vitamin levels on musculoskeletal symptoms. Isotretinoin-induced sacroiliitis and [diffuse idiopathic skeletal hyperostosis (DISH)] emerged as notable musculoskeletal complications. The findings highlight the importance of monitoring patients for potential musculoskeletal side effects and implementing appropriate interventions.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.