ArticleCureus2024
Atypical Cerebral Carcinoids Treated with Hippocampal-Sparing Whole Brain Radiotherapy.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central nervous system (CNS) metastases of atypical carcinoid tumors are exceptionally rare. Isolated studies suggest a survival benefit in patients who receive whole-brain radiotherapy (WBRT); however, it has been known to have detrimental effects on long-term memory and executive function. Here, we present a case of a patient initially diagnosed with stage IIB bronchopulmonary carcinoid who later developed hepatic and intracranial metastases despite receiving adjuvant systemic therapy over a two-year period. She underwent hippocampal-sparing WBRT (HS-WBRT), receiving 30 Gy in 10 fractions via daily image-guided photon therapy using two coplanar arcs. Subsequent clinical evaluations and magnetic resonance imaging (MRI) of the brain at 11 months post-treatment demonstrated a decrease in the size and number of brain metastases, with the patient reporting stable memory and cognition. This case demonstrates the efficacious delivery of palliative HS-WBRT in a patient with a rare presentation of brain-metastatic atypical carcinoid, conferring effective local control and preservation of cognition. Multi-therapy regimens that incorporate HS-WBRT may be considered for improved disease control and quality of life. Further investigation of systemic agents, and possible molecular targets that could confer greater efficacy against treatment-progressive atypical carcinoids, is also warranted.
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