Evidence map›Paper›PMID 39748896›Full record

ReviewNeurology. Education2024

National Institute of Neurological Disorders and Stroke Clinical Trials Methodology Course: Summary and Accomplishments 2014-2023.

Mark Quigg, Laurie Gutmann, Robin A Conwit, Christopher S Coffey, Roger J Lewis, Courtney Miller, William J Meurer

Abstract readReview

In one paragraph

Review in Neurology. Education, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mark QuiggFrom the Department of Neurology (M.Q.), University of Virginia, Charlottesville; Department of Neurology (L.G., R.A.C.), Indiana University, Indianapolis; Department of Biostatistics (C.S.C.), University of Iowa, Iowa City; The Lunquist Institute (R.J.L.), Torrance, CA; and Departments of Emergency Medicine (C.M., W.J.M.), and Neurology (W.J.M.), University of Michigan, Ann Arbor.ORCID https://orcid.org/0000-0003-3035-9260

Laurie GutmannFrom the Department of Neurology (M.Q.), University of Virginia, Charlottesville; Department of Neurology (L.G., R.A.C.), Indiana University, Indianapolis; Department of Biostatistics (C.S.C.), University of Iowa, Iowa City; The Lunquist Institute (R.J.L.), Torrance, CA; and Departments of Emergency Medicine (C.M., W.J.M.), and Neurology (W.J.M.), University of Michigan, Ann Arbor.ORCID https://orcid.org/0000-0003-3926-4209

Robin A ConwitFrom the Department of Neurology (M.Q.), University of Virginia, Charlottesville; Department of Neurology (L.G., R.A.C.), Indiana University, Indianapolis; Department of Biostatistics (C.S.C.), University of Iowa, Iowa City; The Lunquist Institute (R.J.L.), Torrance, CA; and Departments of Emergency Medicine (C.M., W.J.M.), and Neurology (W.J.M.), University of Michigan, Ann Arbor.ORCID https://orcid.org/0000-0001-7650-6698

Christopher S CoffeyFrom the Department of Neurology (M.Q.), University of Virginia, Charlottesville; Department of Neurology (L.G., R.A.C.), Indiana University, Indianapolis; Department of Biostatistics (C.S.C.), University of Iowa, Iowa City; The Lunquist Institute (R.J.L.), Torrance, CA; and Departments of Emergency Medicine (C.M., W.J.M.), and Neurology (W.J.M.), University of Michigan, Ann Arbor.ORCID https://orcid.org/0000-0002-8130-5484

Roger J LewisFrom the Department of Neurology (M.Q.), University of Virginia, Charlottesville; Department of Neurology (L.G., R.A.C.), Indiana University, Indianapolis; Department of Biostatistics (C.S.C.), University of Iowa, Iowa City; The Lunquist Institute (R.J.L.), Torrance, CA; and Departments of Emergency Medicine (C.M., W.J.M.), and Neurology (W.J.M.), University of Michigan, Ann Arbor.

Courtney MillerFrom the Department of Neurology (M.Q.), University of Virginia, Charlottesville; Department of Neurology (L.G., R.A.C.), Indiana University, Indianapolis; Department of Biostatistics (C.S.C.), University of Iowa, Iowa City; The Lunquist Institute (R.J.L.), Torrance, CA; and Departments of Emergency Medicine (C.M., W.J.M.), and Neurology (W.J.M.), University of Michigan, Ann Arbor.

William J MeurerFrom the Department of Neurology (M.Q.), University of Virginia, Charlottesville; Department of Neurology (L.G., R.A.C.), Indiana University, Indianapolis; Department of Biostatistics (C.S.C.), University of Iowa, Iowa City; The Lunquist Institute (R.J.L.), Torrance, CA; and Departments of Emergency Medicine (C.M., W.J.M.), and Neurology (W.J.M.), University of Michigan, Ann Arbor.ORCID https://orcid.org/0000-0002-1158-5302

Funding

Clinical Coordinating Center Network of Excellence in Neuroscience Clinical TrialU01NS077179 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Merit E CUDKOWICZ, Aleksandar Videnovic · 2011 to 2026

$43.4M

Network of Excellence in Neuroscience Clinical Trials (NEXT)-DCCU01NS077352 · NINDS · UNIVERSITY OF IOWA · PI CHRISTOPHER S. COFFEY · 2011 to 2026

$28.1M

Clinical Trials Methodology Course in Neurological DisordersR25NS138633 · NINDS · UNIVERSITY OF VIRGINIA · PI Laurie Gutmann, MARK S QUIGG · 2024 to 2026

$812k

NINDS NIH HHS R25 NS138633NINDS NIH HHS U01 NS077179NINDS NIH HHS U01 NS077352

6 · The paper itself

Abstract

The Clinical Trials Methodology Course (CTMC), given from 2014 to 2023, was conducted to educate early-career clinical investigators from various backgrounds in neurosciences in the design of clinical trials and to provide mentorship to enhance academic careers and retention plus improve research productivity and the likelihood of successful grant applications. This summary describes the rationale, history, structure, and trainee outcomes of the CTMC. The course used small groups, consisting of 1-2 clinical faculty advisor(s), 1 faculty biostatistician, and 2-4 trainees who met remotely approximately weekly over 12 weeks. Faculty and trainees then met for a 4-day in-person residential course. Follow-up activities included 2-3 follow-up remote meetings and a mock study section review of draft grant applications. The CTMC enrolled 243 trainees from 2014 to 2023 (excluding 2020) into Foundation (173) or other (70) tracks. Ninety-six percent of trainees remained in academic positions. Trainees published 7,666 peer-reviewed articles from their enrollment year to 2023 (mean 31.5 articles per trainee, or mean ± SD of 5.0 ± 5.1 articles per year per trainee). There were 7,120 unique articles; trainees were coauthors in 546. Of 173 Foundation Track trainees, 109 (63%) submitted an NIH grant as principal investigator or co-principal investigator, and 68 (62% of 109 submitters) were funded within a median of 3 years after course completion. Of the 243 total trainees, 91 (38%) were principal investigators for at least 1 NIH grant since their course participation to 2023. Trainees have participated as medical monitors, members of data and safety monitoring boards, investigators for NIH research networks, and faculty in the CTMC itself. CTMC has provided a robust foundation in clinical trial methodology in neuroscience research to a generation of clinical investigators.

Identifiers

PMID39748896

DOI10.1212/NE9.0000000000200174

PMCPMC11694788

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.