Evidence map›Paper›PMID 39748675›Full record

ArticleDisease models & mechanisms2025

Prostatic Escherichia coli infection drives CCR2-dependent recruitment of fibrocytes and collagen production.

Brandon R Scharpf, Hannah Ruetten, Jaskiran Sandhu, Kyle A Wegner, Sneha Chandrashekar, Olivia Fox, Anne E Turco, Clara Cole, Lisa M Arendt, Douglas W Strand and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease models & mechanisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Macrophages and TGFB signaling regulate fibrosis in theAmerican journal of physiology. Renal physiology · 2026
    Article
  3. Mechanisms of prostatic inflammation-mediated male lower urinary tract symptoms.American journal of clinical and experimental urology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Brandon R ScharpfDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0002-0308-6968
Hannah RuettenDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Jaskiran SandhuDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Kyle A WegnerDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Sneha ChandrashekarDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Olivia FoxDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Anne E TurcoDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Clara ColeDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Lisa M ArendtDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Douglas W StrandGeorge M. O'Brien Center for Benign Urologic Research, University of Wisconsin-Madison, Madison, WI 53706, USA.
Chad M VezinaDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0001-7058-5399

Funding

UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kathryn Ann O'Donnell · 2010 to 2026
$53.7M
Role of Beta-Catenin in Urinary DysfunctionU54DK104310 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI RICKE, WILLIAM A · 2014 to 2023
$12.8M
REPRODUCTIVE AND DEVELOPMENTAL TOXICITY OF DIOXINR01ES001332 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI PETERSON, RICHARD EUGENE, VEZINA, CHAD M. · 1985 to 2021
$5.3M
Laboratory Animal & Comparative Medicine TrainingT32OD010957 · OD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI J. MARK CLINE · 2012 to 2026
$4.3M
Notch-mediated 5ARI resistance in human BPHR01DK115477 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI STRAND, DOUGLAS WILLIAM · 2018 to 2022
$1.9M
PQ2 Obesity-induced fibrocytes promote breast cancer progressionR01CA227542 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI ARENDT, LISA M · 2018 to 2022
$1.7M
Molecular and fate maps of prostatic stromaU01DK110807 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI VEZINA, CHAD M. · 2016 to 2020
$1.6M
Prostate inflammation increases collagen and voiding dysfunctionF30DK122686 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI RUETTEN, HANNAH MARGARET · 2019 to 2022
$157k
TCDD Reprograms Prostate Stroma and Causes Fibrosis to Induce Urinary DysfunctionF31ES028594 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI WEGNER, KYLE ALLEN · 2018 to 2019
$54k
NCI NIH HHS P30 CA142543NCI NIH HHS R01 CA227542NCI NIH HHS R01CA227542NIDDK NIH HHS F30 DK122686NIDDK NIH HHS F30DK122686NIDDK NIH HHS R01 DK115477NIDDK NIH HHS R01DK115477NIDDK NIH HHS U01 DK110807NIDDK NIH HHS U01DK110807NIDDK NIH HHS U54 DK104310NIDDK NIH HHS U54DK104310NIEHS NIH HHS F31 ES028594NIEHS NIH HHS F31ES028594NIEHS NIH HHS R01 ES001332NIEHS NIH HHS R01ES001332NIH HHS T32 OD010957University of Wisconsin Madison
6 · The paper itself

Abstract

Prostate fibrosis contributes to lower urinary tract dysfunction (LUTD). To develop targeted treatments for prostate fibrosis, it is necessary to identify the cell types and molecular pathways required for collagen production. We used a genetic approach to label and track potential collagen-producing cell lineages in mouse prostate through a round of Escherichia coli UTI89-mediated prostate inflammation. E. coli increased collagen density and production in Gli1+, S100a4+, Lyz2+ and Cd2+ cell lineages, but not in Myh11+ or Srd5a2+ cell lineages, in the mouse prostate. Molecular phenotyping revealed GLI1+LYZ+S100A4+ cells (fibrocytes) in histologically inflamed human prostate. These fibrocytes colocalized with regions of increased collagen in men with LUTD. Fibrocyte recruitment and collagen synthesis was impaired in Ccr2 null mice but restored by allotransplantation of Rosa-GFP donor bone marrow-derived cells. These results suggest that bone marrow-derived fibrocytes are a mediator of prostatic collagen accumulation.

Indexed as

CollagenEscherichia coliEscherichia coli InfectionsProstateReceptors, CCR2AnimalsCell LineageFibrosisHumansInflammationMaleMiceMice, Inbred C57BLCcr2 protein, mouseCollagenReceptors, CCR2CCR2FibrocyteFibrosisLUTDMyofibroblastProstate

Identifiers

PMID39748675
PMCPMC11789281

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.