Evidence map›Paper›PMID 39748617›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2025

A Low-Cost, Open-Source 3D Printer for Multimaterial and High-Throughput Direct Ink Writing of Soft and Living Materials.

Jonathan D Weiss, Alana Mermin-Bunnell, Fredrik S Solberg, Tony Tam, Luca Rosalia, Amit Sharir, Dominic Rütsche, Soham Sinha, Perry S Choi, Masafumi Shibata and 5 more

Abstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Gradient Multinozzle 3D Printing.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jonathan D WeissDepartment of Bioengineering, Stanford University, Stanford, CA, 94305, USA.ORCID https://orcid.org/0000-0002-1033-9206
Alana Mermin-BunnellHarvard-MIT Program in Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID https://orcid.org/0000-0003-1100-6072
Fredrik S SolbergDepartment of Mechanical Engineering, Stanford University, Stanford, CA, 94305, USA.
Tony TamDepartment of Bioengineering, Stanford University, Stanford, CA, 94305, USA.
Luca RosaliaDepartment of Bioengineering, Stanford University, Stanford, CA, 94305, USA.ORCID https://orcid.org/0000-0002-7214-7859
Amit SharirDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID https://orcid.org/0009-0008-2049-3179
Dominic RütscheDepartment of Bioengineering, Stanford University, Stanford, CA, 94305, USA.ORCID https://orcid.org/0000-0001-6394-201X
Soham SinhaDepartment of Bioengineering, Stanford University, Stanford, CA, 94305, USA.
Perry S ChoiDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Masafumi ShibataDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID https://orcid.org/0000-0001-8543-1317
Yellappa PalaganiDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Riya NilkantDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Kiruthika PaulvannanHyde Middle School, Cupertino, CA, 95014, USA.
Michael MaDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Mark A Skylar-ScottDepartment of Bioengineering, Stanford University, Stanford, CA, 94305, USA.ORCID https://orcid.org/0000-0003-3496-7124

Funding

BIOREPOSITORY OF HUMAN INDUCED PLURIPOTENT STEM CELLSFORCARDIOVASCULAR DISEASES (BHIPSC-CVD) - TASK AREA B75N92020D00019 · NHLBI · STANFORD UNIVERSITY · PI WU, JOSEPH · 2021 to 2024
$4.0M
Trillion cell culture to fuel organ biofabricationDP2HL168563 · NHLBI · STANFORD UNIVERSITY · PI SKYLAR-SCOTT, MARK A. · 2022 to 2025
$2.4M
Burroughs Wellcome FundNational Science Foundation ECCS-2026822NHLBI NIH HHS 75N92020D00019NHLBI NIH HHS DP2 HL168563NHLBI NIH HHS DP2HL168563Stanford Cardiovascular Institute Biobank NIH75N92020D00019
6 · The paper itself

Abstract

Direct ink writing is a 3D printing method that is compatible with a wide range of structural, elastomeric, electronic, and living materials, and it continues to expand its uses into physics, engineering, and biology laboratories. However, the large footprint, closed hardware and software ecosystems, and expense of commercial systems often hamper widespread adoption. This work introduces a compact, low-cost, multimaterial, and high-throughput direct ink writing 3D printer platform with detailed assembly files and instructions provided freely online. In contrast to existing low-cost 3D printers and bioprinters, which typically modify off-the-shelf plastic 3D printers, this system is built from scratch, offering a lower cost and full customizability. Active mixing of cell-laden bioinks, high-throughput production of auxetic lattices using multimaterial multinozzle 3D (MM3D) printing methods, and a high-toughness, photocurable hydrogel for fabrication of heart valves are introduced. Finally, hardware for embedded multinozzle and 3D gradient nozzle printing is developed for producing high-throughput and graded 3D parts. This powerful, simple-to-build, and customizable printing platform can help stimulate a vibrant biomaker community of engineers, biologists, and educators.

Indexed as

InkPrinting, Three-DimensionalBioprintingHydrogelsHydrogels3D bioprintingactive mixingauxetic latticeembedded 3D printingmultinozzle

Identifiers

PMID39748617
PMCPMC11899504

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.