Evidence map›Paper›PMID 39748553›Full record

ArticleAnnals of coloproctology2024

Lower pain, less itching, and faster healing after ultrasound scalpel-assisted hemorrhoidectomy using an intimate cleaner containing chlorhexidine, acid hyaluronic acid, and natural anti-inflammatories: a multicenter observational case-control study.

Antonio Brillantino, Luigi Marano, Maurizio Grillo, Alessio Palumbo, Fabrizio Foroni, Luciano Vicenzo, Alessio Antropoli, Michele Lanza, Maria Laura Sandoval Sotelo, Nicola Sangiuliano and 22 more

Abstract read
In one paragraph

Article in Annals of coloproctology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Antonio BrillantinoDepartment of General Surgery, Antonio Cardarelli Hospital, Naples, Italy.
Luigi MaranoDepartment of Medicine, Academy of Applied Medical and Social Sciences (Akademia Medycznych i Społecznych Nauk Stosowanych, AMiSNS), Elbląg, Poland.
Maurizio GrilloDepartment of General Surgery, Antonio Cardarelli Hospital, Naples, Italy.
Alessio PalumboDepartment of General Surgery, Antonio Cardarelli Hospital, Naples, Italy.
Fabrizio ForoniDepartment of General Surgery, Antonio Cardarelli Hospital, Naples, Italy.
Luciano VicenzoDepartment of General Surgery, Antonio Cardarelli Hospital, Naples, Italy.
Alessio AntropoliIRCCS San Raffaele Scientific Institute, Milan, Italy.
Michele LanzaDepartment of General Surgery, Antonio Cardarelli Hospital, Naples, Italy.
Maria Laura Sandoval SoteloDepartment of General Surgery, Antonio Cardarelli Hospital, Naples, Italy.
Nicola SangiulianoDepartment of General Surgery, Antonio Cardarelli Hospital, Naples, Italy.
Mauro MaglioDepartment of General Surgery, Antonio Cardarelli Hospital, Naples, Italy.
Rosanna FilosaDepartment of Science and Technology, University del Sannio, Benevento, Italy.
Lucia AbbatielloDepartment of Science and Technology, University del Sannio, Benevento, Italy.
Maria Preziosa RomanoDepartment of Science and Technology, University del Sannio, Benevento, Italy.
Luana PassarielloUnit of Clinical and Molecular Pathology, University of Campania Luigi Vanvitelli, Naples, Italy.
Pasquale TalentoDepartment of Surgery, Pelvic Floor Center, AUSL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Giovanna IoiaDepartment of General and Oncologic Surgery, Andrea Tortora Hospital, ASL Salerno, Pagani, Italy.
Corrado RispoliUnit of General Surgery, AORN dei Colli, Monaldi Hospital, Naples, Italy.
Mariano Fortunato ArmellinoDepartment of Surgery, Del Mare Hospital, ASL Napoli 1, Naples, Italy.
Vincenzo BottinoUnit of Surgery, Betania Evangelical Hospital, Naples, Italy.
Adolfo RenziDepartment of Surgery, Buonconsiglio Farebenefratelli Hospital, Naples, Italy.
Carlo BartoneDepartment of Surgery, School of Medicine, University of Naples Federico II, Naples, Italy.
Luigi MonacoUnit of Surgery, Villa Hester Clinic, Avellino, Italy.
Paolino MauroDepartment of General Surgery, Antonio Cardarelli Hospital, Naples, Italy.
Stefano PicardiDepartment of General Surgery, Antonio Cardarelli Hospital, Naples, Italy.
Maria Paola MennaDepartment of General Surgery, Antonio Cardarelli Hospital, Naples, Italy.
Elisa PalladinoDepartment of General Surgery, Antonio Cardarelli Hospital, Naples, Italy.
Mario Massimo MensorioDepartment of Health, Antonio Cardarelli Hospital, Naples, Italy.
Vinicio MoscaUnit of General Surgery, G. Moscati Hospital, Aversa, Italy.
Claudio GambardellaDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.
Luigi BruscianoDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.
Ludovico DocimoDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePostoperative pain is a major concern for patients undergoing ultrasound scalpel-assisted hemorrhoidectomy, potentially exacerbated by delayed wound healing. This study aimed to evaluate the impact of an intimate cleansing gel containing chlorhexidine, hyaluronic acid, and other anti-inflammatory agents (Antroclean Fisioderm) on postoperative pain, itching, and wound healing in patients who had undergone this procedure.

methodsThis multicenter observational case-control study involved a cohort of consecutive adult patients who underwent hemorrhoidectomy using an ultrasound device. The study compared 2 different postoperative wound management strategies over 1 month after surgery: washing with warm water twice per day (control group) versus a 2-minute topical application of intimate cleansing gel (Antroclean Fisioderm) followed by a warm water wash (intervention group).

resultsThe median postoperative pain score was significantly lower in the intervention group than in the control group at each follow-up point (P<0.01). The percentage of patients reporting anal itching was also significantly lower in the intervention group than in the control group at each follow-up point (P<0.01). All patients in the intervention group achieved complete wound healing 4 weeks after surgery, compared to 88 (82%) in the control group (P<0.01). No adverse events were reported.

conclusionThe topical application of intimate cleansing gel (Antroclean Fisioderm) twice daily for 1 month following ultrasound scalpel-assisted hemorrhoidectomy appears to be associated with faster healing, reduced pain, decreased itching, and improved quality of life, without any adverse effects. Further larger and prospective randomized trials are recommended to confirm these findings.

Indexed as

Cleansing agentsHemorrhoidectomyHemorrhoidsPruritus aniWound healing

Identifiers

PMID39748553
PMCPMC11701446

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.