Evidence map›Paper›PMID 39748372›Full record

ArticleBehavioral and brain functions : BBF2025

Host genetics maps to behaviour and brain structure in developmental mice.

Sarah Asbury, Jonathan K Y Lai, Kelly C Rilett, Zeeshan Haqqee, Benjamin C Darwin, Jacob Ellegood, Jason P Lerch, Jane A Foster

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioral and brain functions : BBF, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Autobehaver: An AI-Based Pipeline for Animal Behavior Analysis.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sarah AsburyDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Jonathan K Y LaiDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Kelly C RilettDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Zeeshan HaqqeeDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Benjamin C DarwinMouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Jacob EllegoodMouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Jason P LerchMouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Jane A FosterDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada. jane.foster@utsouthwestern.edu.

Funding

CIHR Doctoral: Vanier Canada Graduate ScholarshipsOntario Brain Institute POND
6 · The paper itself

Abstract

Gene-environment interactions in the postnatal period have a long-term impact on neurodevelopment. To effectively assess neurodevelopment in the mouse, we developed a behavioural pipeline that incorporates several validated behavioural tests to measure translationally relevant milestones of behaviour in mice. The behavioral phenotype of 1060 wild type and genetically-modified mice was examined followed by structural brain imaging at 4 weeks of age. The influence of genetics, sex, and early life stress on behaviour and neuroanatomy was determined using traditional statistical and machine learning methods. Analytical results demonstrated that neuroanatomical diversity was primarily associated with genotype whereas behavioural phenotypic diversity was observed to be more susceptible to gene-environment variation. We describe a standardized mouse phenotyping pipeline, termed the Developmental Behavioural Milestones (DBM) Pipeline released alongside the 1000 Mouse Developmental Behavioural Milestones (1000 Mouse DBM) database to institute a novel framework for reproducible interventional neuroscience research.

Indexed as

Behavior, AnimalBrainAnimalsFemaleGene-Environment InteractionGenotypeMaleMiceMice, Inbred C57BLPhenotypeEarly life stressMachine learningNeurodevelopmentRandom forestStructural MRI

Identifiers

PMID39748372
PMCPMC11697848

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.