Evidence map›Paper›PMID 39748368›Full record

ReviewJournal of biomedical science2025

Increasing the biomolecular relevance of cell culture practice.

Raluca E Ghebosu, Lawrence Hui, Joy Wolfram

Abstract readReview
In one paragraph

Review in Journal of biomedical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Rethinking Extracellular Vesicle Signaling.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  3. Integrative Approaches to Treating Cellular Senescence in Kidney Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Raluca E GhebosuAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, 4072, Australia.ORCID https://orcid.org/0000-0001-8839-3512
Lawrence HuiAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, 4072, Australia.
Joy WolframAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, 4072, Australia. j.wolfram@uq.edu.au.ORCID http://orcid.org/0000-0003-0579-9897

Funding

Extracellular vesicle-based senotherapeutics for aging diabetic kidneydiseaseR01AG076537 · NIA · MAYO CLINIC JACKSONVILLE · PI LaTonya J Hickson · 2023 to 2026
$2.3M
NIA NIH HHS R01 AG076537
6 · The paper itself

Abstract

The biomolecular relevance of medium supplements is a key challenge affecting cell culture practice. The biomolecular composition of commonly used supplements differs from that of a physiological environment, affecting the validity of conclusions drawn from in vitro studies. This article discusses the advantages and disadvantages of common supplements, including context-dependent considerations for supplement selection to improve biomolecular relevance, especially in nanomedicine and extracellular vesicle research.

Indexed as

Cell Culture TechniquesCulture MediaExtracellular VesiclesAnimalsHumansNanomedicineCulture MediaChemically defined mediumFetal bovine serum (FBS)PlasmaSerumSupplement

Identifiers

PMID39748368
PMCPMC11697962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.