ArticleCardiovascular diabetology2025
Visceral adipose tissue mediates the relationship between left ventricular global longitudinal strain and insulin resistance among adults living with type 2 diabetes.
Article in Cardiovascular diabetology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Insulin Resistance Indices and Subclinical Left Ventricular Systolic Dysfunction in Adults: A Systematic Review and Meta-Analysis.Reviews in cardiovascular medicine · 2026Pooled it
- Sex differences in insulin resistance and associated metabolic and inflammatory markers among adults with and without HIV in Zambia.Physiological reports · 2026Article
- Visceral Adiposity Is Independently Associated with Hypertension in Thai Adults: A Case-Control Study.International journal of environmental research and public health · 2026Article
- Rethinking cardiometabolic therapy thresholds in individuals with obesity.International journal of obesity (2005) · 2026Review
- Triglyceride-Glucose-Waist-to-Weight Index: Novel Biomarker for Mild Cognitive Impairment in Older People With Sarcopenic Obesity.Journal of cachexia, sarcopenia and muscle · 2026Article
- Digital-Assisted Nutritional Monitoring and Body Composition Changes in Aging Adults: A 6-Month Controlled Longitudinal Study.Nutrients · 2026Article
- Ectopic fat distribution and its correlation with insulin resistance indices in non-obese individuals with type 2 diabetes.Acta diabetologica · 2026Article
- Review
- Review
- HDL-C and systemic inflammatory response index mediate the association between visceral adipose tissue and risk of cardiovascular disease among young and middle-aged adults with prediabetes or diabetes: a national cohort study.Journal of translational medicine · 2025Article
- Review of Hyperbaric Oxygen Therapy as an Adjunctive Intervention for Metabolic Disorders.Antioxidants (Basel, Switzerland) · 2025Review
- Chinese visceral adiposity index predicts all-cause mortality in patients with type 2 diabetes, heart failure, and chronic kidney disease: a retrospective cohort study.BMC research notes · 2025Article
- The predictive value of atherogenic index of plasma and clonal hematopoiesis of indeterminate potential among patients with STEMI-from a prospective cohort study.Cardiovascular diabetology · 2025Article
- Epicardial adipose tissue volume is associated with impaired left ventricular strain in patients with metabolic syndrome: the mediating role of myocardial energetic efficiency.Cardiovascular diabetology · 2025Article
- Correction: Visceral adipose tissue mediates the relationship between left ventricular global longitudinal strain and insulin resistance among adults living with type 2 diabetes.Cardiovascular diabetology · 2025Article
- Atherogenic index of plasma, high sensitivity C-reactive protein and incident diabetes among middle-aged and elderly adults in China: a national cohort study.Cardiovascular diabetology · 2025Article
- Clinical correlates of perivascular adipose tissue in coronary artery disease and obesity.Frontiers in physiology · 2025Article
- Association between metabolic score for visceral fat and chronic pain: a cross-sectional analysis of NHANES 1999-2004.Frontiers in nutrition · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdipose tissue distribution plays a crucial role in the development of cardiovascular complications. In particular, visceral adipose tissue (VAT) has been linked to insulin resistance (IR) and cardiovascular disease (CVD). However, the relationship between VAT, cardiac dysfunction and the meditation capacity of VAT related to IR has not been fully characterized.
methodsThis cross-sectional study included adults living with type 2 diabetes (T2D). VAT was measured using electrical bioimpedance and also estimated with the Metabolic Score for Visceral Fat (METS-VF). LV function was assessed using left ventricular global longitudinal strain (LV-GLS) by speckle tracking echocardiography analysis. Spearman correlation coefficients, adjusted linear regression models guided by direct acyclic diagrams and causal mediation analysis were performed.
resultsAmong 195 adults living with T2D (median age: 57, IQR: 49-64, women: 63%), VAT showed a positive association with LV-GLS (β = 0.482, 95% CI: 0.060-0.904, p = 0.039) after adjusting for relevant confounders. The effect was strongly replicated using METS-VF as a surrogate for VAT. The mediation analysis revealed that VAT accounted for 60.9% (95% CI: 15.82-171) of the total effect between IR and LV-GLS.
conclusionThis study demonstrated a positive association between VAT and LV-GLS. This relationship was consistently observed using the clinical surrogate METS-VF. Visceral adiposity was identified as a strong mediator in the relationship between IR and LV-GLS, underscoring its role in the pathophysiology of cardiovascular disease in patients with T2D.
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