Evidence map›Paper›PMID 39748330›Full record

ArticleBMC psychiatry2025

Shared and distinct morphometric similarity network abnormalities in generalized anxiety disorder, posttraumatic stress disorder and social anxiety disorder.

Guifeng Tan, Minlan Yuan, Lun Li, Hongru Zhu, Su Lui, Changjian Qiu, Wei Zhang

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guifeng Tan *Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, No. 37 GuoXue Xiang, Chengdu, 610041, P. R. China.
Minlan Yuan *Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, No. 37 GuoXue Xiang, Chengdu, 610041, P. R. China.
Lun LiMental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, No. 37 GuoXue Xiang, Chengdu, 610041, P. R. China.
Hongru ZhuMental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, No. 37 GuoXue Xiang, Chengdu, 610041, P. R. China.
Su LuiHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, 610041, P. R. China.
Changjian QiuMental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, No. 37 GuoXue Xiang, Chengdu, 610041, P. R. China.
Wei ZhangMental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, No. 37 GuoXue Xiang, Chengdu, 610041, P. R. China. weizhanghx@163.com.

Funding

Institutional Research Fund from Sichuan University 2022SCUH0026Med-X Center for Informatics funding project YGJC012National Natural Science Foundation of China 81871061National Natural Science Foundation of China 82171513Postdoctoral Foundation of West China Hospital 2020HXBH041the 1·3·5 project for disciplines of excellence, West China Hospital, Sichuan University ZYJC21004the 1·3·5 project for disciplines of excellence, West China Hospital, Sichuan University ZYJC21069the 1·3·5 project for disciplines of excellence, West China Hospital, Sichuan University ZYJC21083
6 · The paper itself

Abstract

backgroundThe high comorbidity and symptom overlap of generalized anxiety disorder (GAD), posttraumatic stress disorder (PTSD), and social anxiety disorder (SAD), has led to the study of their shared and disorder-specific neural substrates. However, the morphometric similarity network (MSN) differences among these disorders remain unknown.

methodsMSN derived from T1-weighted images in patients of GAD, PTSD, and SAD, and health controls (HC) using a Siemens 3T magnetic resonance imaging system. Covariance analysis and post hoc tests were used to investigate group differences. In addition, the relationship between MSN and clinical characteristics was analyzed.

resultsIncreased morphometric similarity (MS) between left bankssts (BA22, superior temporal cortex, STC) and right precentral gyrus, and decreased MS between left precentral gyrus and right cuneus_part1/part2, and between right rostral middle frontal cortex (rMFC) and right STC were common in GAD and PTSD relative to HC and SAD. Compared to the other three groups, SAD exhibited disorder-specific alterations of increased MS between right rMFC and right STC, and between left cuneus and right inferior parietal cortex. Additionally, increased regional MSN in left precentral gyrus was found in PTSD compared to HC and SAD. A mild positive correlation of the MS value between left bankssts and right precentral gyrus and the Hamilton Anxiety Rating Scale scores (uncorrected p = 0.041) was found in PTSD.

conclusionsOur study provides the first evidence for common and distinct brain MSN abnormalities underlying the pathophysiology of GAD, PTSD, and SAD, which may aid in differential diagnosis and determining potential disorder-specific intervention targets.

Indexed as

Anxiety DisordersMagnetic Resonance ImagingPhobia, SocialStress Disorders, Post-TraumaticAdultBrainFemaleHumansMaleMiddle AgedNerve NetYoung AdultGeneralized anxiety disorderMorphometric similarity networkPosttraumatic stress disorderSocial anxiety disorder

Identifiers

PMID39748330
PMCPMC11697831

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.