Evidence map›Paper›PMID 39748216›Full record

ArticleBritish journal of haematology2025

Systemic lupus erythematosus-associated autoantibodies in sickle cell disease: Spontaneous emergence in a patient and in transgenic sickle mice.

Urshita Sinha, Suman Setty, Céleste Pilon, Julia J Brown, Maria Armila Ruiz, Guohui Ren, Joyce Rauch, Santosh L Saraf, Jerrold S Levine

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Urshita SinhaDivision of Nephrology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
Suman SettyDepartment of Pathology, University of Illinois at Chicago, Chicago, Illinois, USA.
Céleste PilonDivision of Rheumatology, Department of Medicine, McGill University & Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Julia J BrownDivision of Nephrology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
Maria Armila RuizDivision of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
Guohui RenDivision of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
Joyce RauchDivision of Rheumatology, Department of Medicine, McGill University & Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Santosh L SarafDivision of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-8584-4194
Jerrold S LevineDivision of Nephrology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0003-0158-6675

Funding

Pathways of Cell-Free Hemoglobin in Sickle Cell NephropathyR01HL153161 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SARAF, SANTOSH · 2020 to 2024
$2.0M
Mentoring & Patient-Oriented Research in Sickle Cell-Related Kidney DiseaseK24HL177273 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Santosh Saraf · 2025 to 2026
$274k
CIHR PJT159652NHLBI NIH HHS K24 HL177273NHLBI NIH HHS R01 HL153161NIH HHS R01-HL153161
6 · The paper itself

Abstract

We describe a patient with sickle cell disease (SCD) and elevated antiphospholipid antibodies (aPL) who developed multi-organ failure resembling catastrophic antiphospholipid syndrome. Autoimmune screening revealed several autoantibodies characteristic of systemic lupus erythematosus (SLE). Notably, routinely housed and unmanipulated transgenic sickle mice displayed significantly elevated titres of aPL- and SLE-associated autoantibodies. We hypothesize that SCD may be a risk factor not only for the development of aPL but also more widespread autoimmunity.

Indexed as

Anemia, Sickle CellAntibodies, AntiphospholipidAutoantibodiesLupus Erythematosus, SystemicAdultAnimalsHumansMaleMiceMice, TransgenicAntibodies, AntiphospholipidAutoantibodiesantiphospholipid antibodyantiphospholipid syndromeautoimmunitysickle cell diseasesystemic lupus erythematosusTownes model

Identifiers

PMID39748216
PMCPMC11985294

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.