Evidence map›Paper›PMID 39748192›Full record

ArticleClinical and translational medicine2025

Exosome-derived long non-coding RNA AC010789.1 modified by FTO and hnRNPA2B1 accelerates growth of hair follicle stem cells against androgen alopecia by activating S100A8/Wnt/β-catenin signalling.

Shaojun Chu, Lingling Jia, Yulong Li, Jiachao Xiong, Yulin Sun, Qin Zhou, Dexiang Du, Zihan Li, Xin Huang, Hua Jiang and 2 more

Abstract read
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In one paragraph

Article in Clinical and translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shaojun ChuDepartment of Plastic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Lingling JiaDepartment of Plastic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Yulong LiDepartment of Military Medical Psychology, Air Force Medical University, Xi'an, China.
Jiachao XiongDepartment of Plastic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Yulin SunDepartment of Plastic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Qin ZhouDepartment of Plastic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Dexiang DuDepartment of Plastic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Zihan LiSt Hugh's College, University of Oxford, Oxford, UK.
Xin HuangDepartment of Dermatology, Hair Medical Center of Shanghai Tongji Hospital, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Hua JiangDepartment of Plastic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Baojin WuDepartment of Plastic Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Yufei LiDepartment of Plastic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0002-5878-3162

Funding

Clinical Research Plan SEHHH-2021(KJ)-0669-KJB-485Clinical Research Plan SEHHH-2023(KJ)-0143-KYB-111National Natural Science Foundation of China 82073452Natural Foundation Project of Shanghai Science and Technology Commission 17ZR1426300the Ministry of Education of China 231103242232720
6 · The paper itself

Abstract

backgroundThe increased incidence of androgenic alopecia (AGA) causes adverse physiological and psychological effects on people of all genders. The hair follicle stem cells (HFSCs) have displayed clinical improvements on AGA. However, the molecular mechanism of HFSCs against AGA remains elusive.

methodsThe expression and prognosis of lncRNA AC010789.1 in AGA hair follicle tissues were assessed by qRT-PCR analysis. CCK-8, EdU and Transwell analysis were utilized to assess cell growth. The specific binding between AC010789.1 and FTO mediated m

resultsWe herein found that the mRNA levels of lncRNA AC010789.1 were decreased in AGA tissue samples but increased in HFSCs of surrounding normal tissue samples. Overexpression (OE) of AC010789.1 promoted HFSC proliferation, DNA synthesis and migration as well as K6HF and Lgr5 upregulation, whereas knockdown of AC010789.1 showed the opposite effects. The total or AC010789.1 m

conclusionsOur findings demonstrated that exosome-derived lncRNA AC010789.1 modified by FTO and hnRNPA2B1 facilitated the proliferation of human HFSCs against AGA by activating S100A8/Wnt/β-catenin signaling. KEY POINTS: Long non-coding RNA (lncRNA) AC010789.1 was downregulated in hair follicle tissues from androgenic alopecia (AGA) and upregulated in hair follicle stem cells (HFSCs). LncRNA AC010789.1 promoted the proliferation and migration of HFSCs. FTO/hnRNPA2B1-mediated m

Indexed as

AlopeciaAlpha-Ketoglutarate-Dependent Dioxygenase FTOHair FollicleRNA, Long NoncodingStem CellsWnt Signaling PathwayAnimalsCalgranulin ACell ProliferationExosomesHumansMaleMiceAlpha-Ketoglutarate-Dependent Dioxygenase FTOCalgranulin AFTO protein, humanRNA, Long NoncodingFTOHFSCshnRNPA2B1lncRNA AC010789.1proliferationS100A8

Identifiers

PMID39748192
PMCPMC11695201

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.