Evidence map›Paper›PMID 39748114›Full record

ArticleScientific reports2025

Modeling synergy and individual effects of X-ray induced photodynamic therapy components.

Farideh S Hossein, Nadia Naghavi, Ameneh Sazgarnia, Atefeh Vejdani Noghreiyan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Farideh S HosseinDepartment of Electrical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran.
Nadia NaghaviDepartment of Electrical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran. nn.naghavi@gmail.com.
Ameneh SazgarniaMedical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Atefeh Vejdani NoghreiyanDepartment of Medical Physics, Faculty of Medicine, University of Medical Sciences, Mashhad, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

X-ray induced photodynamic therapy (XPDT) utilizes self-lighting nanoparticles to combine the benefits of radiotherapy and photodynamic therapy. These nanomaterials transform X-ray to visible light that can be absorbed by nearby photosensitizers and in the presence of surrounding oxygen molecules generates reactive oxygen species, which are very toxic to the cells. Despite many studies conducted on modelling XPDT, little focused on the contribution of each component as well as their synergy effects. We developed a multiscale physicochemical model of XPDT to incorporate the key role of molecular oxygen in PDT component efficiency. Simultaneously, the effects of RT in the presence of TiO

Indexed as

PhotochemotherapyPhotosensitizing AgentsApoptosisHT29 CellsHumansNanoparticlesReactive Oxygen SpeciesTitaniumX-RaysPhotosensitizing AgentsReactive Oxygen SpeciesTitaniumtitanium dioxideModeling XPDTNanoscintillatorPhysiochemical modelSinglet oxygen productionSynergy effectsX-ray induced photodynamic therapy

Identifiers

PMID39748114
PMCPMC11696517

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.