Evidence map›Paper›PMID 39748081›Full record

ArticleScientific reports2025

Heart-retina time analysis using electrocardiogram-coupled time-resolved dynamic optical coherence tomography.

Philippe Valmaggia, Julia Wolleb, Florentin Bieder, Hendrik P N Scholl, Philippe C Cattin, Peter M Maloca

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Philippe ValmaggiaDepartment of Biomedical Engineering, University of Basel, Hegenheimermattweg 167b/c, 4123, Allschwil, Switzerland. philippe.valmaggia@unibas.ch.
Julia WollebDepartment of Biomedical Engineering, University of Basel, Hegenheimermattweg 167b/c, 4123, Allschwil, Switzerland.
Florentin BiederDepartment of Biomedical Engineering, University of Basel, Hegenheimermattweg 167b/c, 4123, Allschwil, Switzerland.
Hendrik P N SchollDepartment of Ophthalmology, University Hospital Basel, Mittlere Strasse 91, 4031, Basel, Switzerland.
Philippe C Cattin *Department of Biomedical Engineering, University of Basel, Hegenheimermattweg 167b/c, 4123, Allschwil, Switzerland.
Peter M Maloca *Institute of Molecular and Clinical Ophthalmology Basel (IOB), Mittlere Strasse 91, 4031, Basel, Switzerland.

Funding

Schweizerische Akademie der Medizinischen Wissenschaften YTCR 43/23Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 323530_199395
6 · The paper itself

Abstract

The eye and the heart are two closely interlinked organs, and many diseases affecting the cardiovascular system manifest in the eye. To contribute to the understanding of blood flow propagation towards the retina, we developed a method to acquire electrocardiogram (ECG) coupled time-resolved dynamic optical coherence tomography (OCT) images. This method allows for continuous synchronised monitoring of the cardiac cycle and retinal blood flow dynamics. The dynamic OCT measurements were used to calculate time-resolved blood flow profiles using fringe washout analysis. The relative fringe washout was computed to generate the flow velocity profiles within arterioles at the optic nerve head rim. We found that the blood column between the heart and the retina propagates within one cardiac cycle, denoting the arrival time as the heart-retina time (HRT). In a group of healthy subjects, the HRT was 144 ± 19 ms (mean ± SD). The HRT could provide a novel potential biomarker for cardiovascular health in direct relation to retinal perfusion.

Indexed as

ElectrocardiographyHeartRetinaTomography, Optical CoherenceAdultBlood Flow VelocityFemaleHumansMaleMiddle AgedRetinal VesselsCardiac cycleDynamic optical coherence tomographyElectrocardiogramHeart-retina timeRetinal blood flow

Identifiers

PMID39748081
PMCPMC11697082

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.