ArticleEuropean journal of clinical nutrition2025
Myosteatosis is associated with adiposity, metabolic derangements and mortality in patients with chronic kidney disease.
Article in European journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- PET/CT-derived whole-body composition and survival in resectable NSCLC: double machine learning-based adjusted association analysis of intermuscular adiposity burden and sex-specific metabolic phenotypes.European journal of nuclear medicine and molecular imaging · 2026Article
- Fully automated CT-based quantitative body composition analysis for predicting survival in patients with HCC undergoing TACE: a dual-cohort study.Scientific reports · 2026Article
- Adverse Muscle Composition Is Associated with All-Cause Mortality in CKD: A UK Biobank Imaging Study.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Deep Learning-Derived Body Composition Analysis Predicts Long-Term Mortality After Transcatheter Aortic Valve Replacement.Mayo Clinic proceedings. Digital health · 2026Article
- Unravelling Sarcopenia in Chronic Kidney Disease: From Pathogenesis to Diagnosis and Therapeutics.Diagnostics (Basel, Switzerland) · 2026Review
- CT-Derived Body Composition and Diet Quality in Kidney Transplant Recipients: A Single-Center Retrospective Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2026Article
- Beyond body mass index: phenotypic and circulating biomarkers for the identification and characterization of sarcopenic obesity.Frontiers in nutrition · 2026Review
- Myosteatosis: Epidemiological Insights, Functional Decline, and Diagnostic Advances.Current obesity reports · 2025Review
- The Impact of Sarcopenia, Myosteatosis, and Visceral Adiposity on Renal Transplantation Outcomes.Medicina (Kaunas, Lithuania) · 2025Article
- Intermuscular adipose tissue and muscle function in patients on maintenance hemodialysis.Physiological reports · 2025Article
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6 authors.
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Abstract
BACKGROUND/
objectivesMyosteatosis has been associated with sarcopenia, and increased mortality risk in patients on hemodialysis. We aimed to explore the associations between myosteatosis, as assessed by computed tomography (CT), with demographic parameters, body composition metrics, muscle strength, metabolic parameters and mortality in patients with chronic kidney disease (CKD). SUBJECTS/
methodsWe enrolled 216 patients (age 60.3 ± 10.6 years, 63% men) with CKD stages 3-5. Abdominal CT scans at the third lumbar vertebra (L3) were used to assess body composition. Abdominal obesity was determined by abdominal adipose tissue (AT), sarcopenia by low skeletal muscle area (SMA) and low handgrip strength. Myosteatosis was evaluated by two parameters using CT scans at L3: mean muscle attenuation and percentage of intermuscular adipose tissue (%IMAT) within SMA. We evaluated the correlation between parameters of myosteatosis with demographic, clinical and metabolic variables. To determine independent predictors of myosteatosis, a multiple linear regression model was fitted. Mortality risk was evaluated with Cox-regression analysis.
resultsBoth parameters of myosteatosis were independently associated with age, metabolic syndrome, abdominal AT and SMA in the multiple linear regression analysis (adjusted R
conclusionIn patients with CKD, increased myosteatosis, as assessed by abdominal CT, was associated with old age, adiposity, metabolic dysfunction, and higher mortality risk.
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