Evidence map›Paper›PMID 39748000›Full record

ArticleScientific reports2025

Amblyopic binocular imbalance quantified by the dichoptic contrast ordering test and dichoptic letters test.

Alexandre Reynaud, Marie-Céline Lorenzini, Robert K Koenekoop, Robert F Hess, Alex S Baldwin

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexandre ReynaudDepartment Ophthalmology and Visual Sciences, McGill Vision Research, McGill University, Montreal, QC, Canada. alexandre.reynaud@mcgill.ca.
Marie-Céline LorenziniBRaIN Program, Research Institute of the McGill University Health Center, Montreal, QC, Canada.
Robert K KoenekoopDepartment of Pediatric Surgery, Human Genetics and Ophthalmology, Montreal Children's Hospital, McGill University, Montreal, QC, Canada.
Robert F HessDepartment Ophthalmology and Visual Sciences, McGill Vision Research, McGill University, Montreal, QC, Canada.
Alex S BaldwinDepartment Ophthalmology and Visual Sciences, McGill Vision Research, McGill University, Montreal, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In amblyopia, abnormal binocular interactions lead to an overwhelming dominance of one eye. One mechanism implied in this imbalance is the suppression between the inputs from the two eyes. This interocular suppression involves two components: an overlay suppression and a surround suppression. Here, we propose a new method for measuring surround suppression which has been demonstrated in both strabismic and anisometropic amblyopes, based on a novel interocular contrast scaling task, suitable for use as a clinical tool. We compare the results obtained with this method against those from another method designed to measure overlay suppression: the Dichoptic Letter Test. We find a strong correlation between the results obtained with the two methods. Additionally, we observe strong correlations between the imbalance measured with the two tests and visual acuity and stereopsis. Altogether this suggests that amblyopic suppression is spatially broad and has direct relevance in global vision. So our new method is a relevant, clinically suitable tool to track the disease state in amblyopia.

Indexed as

AmblyopiaVision, BinocularVisual AcuityAdolescentAdultContrast SensitivityDepth PerceptionFemaleHumansMaleMiddle AgedVision TestsYoung Adult

Identifiers

PMID39748000
PMCPMC11696884

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.