ArticleScientific reports2025
Association between systemic immune inflammation index and cataract incidence from 2005 to 2008.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- A multimodal ocular aging index reveals proteomic pathways and predicts incident age-related eye diseases.npj aging · 2026Article
- The Relationship of the Red Cell Distribution Width-to-Albumin Ratio and Other Inflammatory Markers With Cataracts: An Analysis of the NHANES Population.Translational vision science & technology · 2026Article
- Association between inflammatory biomarkers and cataracts: validation from the NHANES database and clinical studies.Frontiers in nutrition · 2026Article
- The Association Between Sleep Health and a History of Cataract Surgery in the United States Based on the National Health and Nutrition Examination Survey (NHANES) 2005-2008.Healthcare (Basel, Switzerland) · 2025Article
- Ameliorating effect of the aldose reductase inhibitor 1-Acetyl-5-phenyl-1 H-pyrrol-3-ylacetate on galactose-induced cataract.Scientific reports · 2025Article
- Association of systemic inflammatory biomarkers with ocular disease: a large population-based cross-sectional study.European journal of medical research · 2025Article
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Authors and funding
7 authors.
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Abstract
The objective of this study is to investigate the association between the Systemic Immune-Inflammation Index (SII) and cataracts. This cross-sectional study analyzed data from the 2005-2008 NHANES to examine the relationship between the SII and cataract prevalence. Covariates included age, race/ethnicity, gender, education level, marital status, Body Mass Index (BMI), smoking, alcohol consumption, hypertension, hyperlipidemia, and diabetes. Multivariable logistic regression was used to assess the association, while spline curve fitting explored potential non-linear relationships. Threshold analysis identified critical inflection points. To address age-related bias, Propensity Score Matching (PSM) was performed, aligning cataract patients with comparable non-cataract individuals for further evaluation. Our study included 3,623 participants, of whom 730 (20.15%) were diagnosed with cataracts. After adjusting for all covariates, multivariable logistic regression analysis demonstrated that elevated levels of the SII were significantly associated with increased odds of cataracts (Model1: OR = 1.56; 95%CI [1.33-1.85]; Model2: OR = 1.55; 95%CI [1.32-1.84]; Model3: OR = 1.57; 95%CI [1.33-1.86]). In the spline curve fitting model, the relationship between ln-SII and cataract prevalence was non-linear (P < 0.001), with a critical inflection point identified at an SII of 428.38. SII levels remained significantly associated with cataract prevalence following PSM adjustments (Model 1: OR = 1.48; 95% CI [1.21-1.80]; Model 2: OR = 1.48; 95% CI [1.21-1.80]; Model 3: OR = 1.46; 95% CI [1.20-1.78]). Elevated SII levels are associated with a higher prevalence of cataracts, underscoring the pivotal role of systemic inflammation in cataract development. These findings indicate that SII could serve as a valuable biomarker for assessing cataract risk, further emphasizing the significance of managing systemic inflammation as a potential strategy for cataract prevention.
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