ArticleScientific reports2025
Association of pre-exiting heart failure with long-term mortality and the recurrence of sepsis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Response to Dobutamine in Septic Shock With Myocardial Dysfunction: A Single-Center Retrospective Study.Critical care explorations · 2026Article
- Impact of hospitalization in an acute geriatric ward after ICU discharge for patients aged 80 and over: a cohort study.European geriatric medicine · 2026Article
- Phenotypes and Outcomes of Heart Failure First Diagnosed During Sepsis: A Single-Center Retrospective Cohort Study Using ICD-10-Based Subtype Classification.Journal of clinical medicine · 2026Article
- Stress Hyperglycemia Ratio and the Risk of Sepsis in Patients With Heart Failure: Retrospective Cohort Study From Medical Information Mart for Intensive Care-IV.JMIR medical informatics · 2026Article
- Machine learning prediction of sepsis in paralytic ileus using interpretable clinical models.Frontiers in cellular and infection microbiology · 2026Article
- Nationwide trends and disparities in deaths following cardiogenic shock and sepsis in the United States (1999-2023): insights from the CDC WONDER database.BMC cardiovascular disorders · 2025Article
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11 authors.
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Abstract
This retrospective cohort study aimed to evaluate the association between pre-existing heart failure and both mortality and the recurrence of sepsis. A total of 16,092 sepsis patients without a history of heart failure and 841 sepsis patients with pre-existing heart failure were identified from the Medical Information Mart for Intensive Care version IV (MIMIC-IV ) database. All patients were adults admitted to intensive care units, and no specific interventions were applied. After matching, Kaplan-Meier survival analysis showed significantly poorer long-term survival rates in patients with heart failure, both in the original (p < 0.0001) and the matched cohort (p = 0.00059). Mortality rates were tracked over different time periods, revealing that the mortality disparity became evident after the first year (p = 0.029). Besides, the cumulative incidence of sepsis recurrence was substantially higher in patients with a history of heart failure (p < 0.001) when deaths without recurrence were treated as competing events. Moreover, there was no statistically significant difference observed in the deaths without recurrence between the two groups (p = 0.251). In conclusion, pre-existing heart failure is associated with an increased risk of long-term mortality, which may be partly explained by a higher incidence of recurrent sepsis in this population.
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