Evidence map›Paper›PMID 39747887›Full record

Trial reportScientific reports2025

Capsaicin-induced secondary hyperalgesia differences between the trigeminal and spinal innervation.

Isabela C Novaes, Soraya S Ardestani, Allen Matheus S Nascimento, Paulo C R Conti, Leonardo R Bonjardim, Peter Svensson, Fernando G Exposto, Yuri M Costa

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Isabela C NovaesDepartment of Biosciences, Universidade Estadual de Campinas (UNICAMP), Faculdade de Odontologia de Piracicaba (FOP), Piracicaba, Brazil.
Soraya S ArdestaniDepartment of Biosciences, Universidade Estadual de Campinas (UNICAMP), Faculdade de Odontologia de Piracicaba (FOP), Piracicaba, Brazil.
Allen Matheus S NascimentoDepartment of Biosciences, Universidade Estadual de Campinas (UNICAMP), Faculdade de Odontologia de Piracicaba (FOP), Piracicaba, Brazil.
Paulo C R ContiDepartment of Prosthetic Dentistry, Bauru School of Dentistry, University of Sao Paulo, Bauru, Sao Paulo, Brazil.
Leonardo R BonjardimSection of Head and Face Physiology, Department of Biological Sciences, Bauru School of Dentistry, University of Sao Paulo, Bauru, São Paulo, Brazil.
Peter SvenssonFaculty of Dentistry, National University of Singapore, Singapore, Singapore.
Fernando G ExpostoSection for Orofacial Pain and Jaw Function, Department of Dentistry and Oral Health, Aarhus University, Vennelyst Boulevard 9, 8000, Aarhus, Denmark. fernando.exposto@dent.au.dk.
Yuri M CostaDepartment of Biosciences, Universidade Estadual de Campinas (UNICAMP), Faculdade de Odontologia de Piracicaba (FOP), Piracicaba, Brazil.

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/15826-8
6 · The paper itself

Abstract

This study compared the degree of secondary hyperalgesia and somatosensory threshold changes induced by topical capsaicin between spinal and trigeminal innervation. This crossover clinical trial included 40 healthy individuals in which 0.25 g of 1% capsaicin cream was randomly applied for 45 minutes to a circular area of 2 cm

Indexed as

CapsaicinHyperalgesiaPain ThresholdAdultCross-Over StudiesFemaleForearmHumansMaleMasseter MuscleSpinal NervesTrigeminal NerveYoung AdultCapsaicinCapsaicinCentral sensitizationOrofacial painSecondary hyperalgesia

Identifiers

PMID39747887
PMCPMC11696148

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.