Evidence map›Paper›PMID 39747770›Full record

Trial reportJournal of general internal medicine2025

Influence of Neighborhood Socioeconomic Deprivation on Effectiveness of an Intensive Lifestyle Intervention.

Mamadou Sy, Scott Pilla, Wendy Bennett, Hsin-Chieh Yeh, Kesha Baptiste-Roberts, Tiffany L Gary-Webb, Dhananjay Vaidya, Jeanne M Clark

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of general internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mamadou SyDepartment of Global and Community Health, College of Public Health, George Mason University, Fairfax, VA, USA. msy@gmu.edu.ORCID 0009-0006-2453-7365
Scott PillaDepartment of Medicine, Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Wendy BennettDepartment of Medicine, Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Hsin-Chieh YehDepartment of Medicine, Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Kesha Baptiste-RobertsDepartment of Public & Allied Health, School of Community Health & Policy, Morgan State University, Baltimore, MD, USA.
Tiffany L Gary-WebbDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Dhananjay VaidyaDepartment of Medicine, Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Jeanne M ClarkDepartment of Medicine, Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Funding

STUDY OF HEALTH OUTCOMES OF WEIGHT-LOSS (SHOW)U01DK057149 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI CLARK, JEANNE M · 1999 to 2020
$17.4M
Washington University Center for Diabetes Translation Research P30DK092950 · NIDDK · WASHINGTON UNIVERSITY · PI Ross C Brownson, Debra Haire-Joshu · 2011 to 2026
$11.7M
Racial Disparities in Obesity: Role of Culture and EnviornmentK01HL084700 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI GARY-WEBB, TIFFANY L · 2006 to 2010
$680k
NHLBI NIH HHS K01 HL084700NHLBI NIH HHS K01-HL084700NIDDK NIH HHS K-24DK6222NIDDK NIH HHS P30 DK092950NIDDK NIH HHS U01 DK057149NIDDK NIH HHS U01-DK57149
6 · The paper itself

Abstract

objectiveTo assess the influence of neighborhood socioeconomic deprivation on the effectiveness of an intensive lifestyle intervention (ILI) in the Look AHEAD trial. RESEARCH DESIGN AND

methodsLook AHEAD randomized adults with overweight/obesity and type 2 diabetes to ILI for weight loss, or Diabetes Support and Education (DSE). We linked participant data from four study sites to the 2000 United States Census to generate a neighborhood socioeconomic deprivation score. We analyzed the effect of neighborhood deprivation in tertiles on various clinical outcomes including weight and HbA1c changes over 4 years using a mixed-effects linear model with random intercept and an interaction term between deprivation tertile and study arm over 4 years.

resultsAmong 1213 participants at baseline, the mean age was 60 years, 41% were male, and 65% identified as White, 26% as Black, and 4% as Hispanic. Most participants had a college degree (84%) and reported an annual income over $40,000 (75%). The deprivation score ranged from -12.04 to -2.61 in the most deprived tertile and 2.01 to 18.69 in the least deprived tertile (the lower the score, the higher the deprivation). There were no statistically significant treatment differences by deprivation score in weight or HbA1c changes over the 4-year period.

conclusionsIn this clinical trial population, an intensive lifestyle intervention was equally effective across levels of neighborhood socioeconomic deprivation. However, these findings may not extend to individuals with the lowest income and educational attainment who are not typically represented in clinical trials and for whom more research is needed.

Indexed as

Diabetes Mellitus, Type 2Life StyleNeighborhood CharacteristicsObesityAgedFemaleHumansMaleMiddle AgedSocioeconomic FactorsTreatment OutcomeUnited StatesWeight Losslifestyle interventionneighborhood deprivationobesityolder adultstype 2 diabetes

Identifiers

PMID39747770
PMCPMC12119450

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.