SynthesisInfection2025
Adenovirus nephritis in adult kidney allograft recipients: a systematic review of literature.
Synthesis in Infection, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Severe adenovirus-associated pneumonia complicated by biopsy-evaluated acute kidney injury in an immunocompetent adult: a case report.BMC nephrology · 2026Article
- Article
- Neural stem cell-delivered oncolytic virus via intracerebroventricular administration enhances glioblastoma therapy and immune modulation.Journal for immunotherapy of cancer · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdenovirus nephritis is an increasingly recognized complication in adult kidney transplant recipients, characterized by its diverse clinical presentations and diagnostic challenges. This systematic review summarises the clinical profiles and outcomes of adenoviral nephritis in kidney allograft recipients.
methodsWe conducted a systematic search of PubMed, Embase, and Web of Science for studies (case reports or series) with individual patient data on adult kidney transplant recipients with confirmed or presumptive adenoviral nephritis up to October 2, 2024. Clinical profile, treatment and outcome data with adenoviral nephritis were collected and summarised for all patients. We compared features of early and late adenoviral nephritis (diagnosis before and after 90 days post-transplantation).
resultsThirty-nine studies met inclusion criteria, involving 57 patients with a mean age of 45.7 years and a male predominance. The median time to infection post-transplant was 168 days. The most common symptoms were fever (68.5%), dysuria (49%) and diarrhoea (21%). Early adenoviral infection was more common in cadaveric graft recipients. Fever and gross haematuria were more common in late adenoviral infections. Biopsies showed interstitial nephritis (100%), with some having acute tubular necrosis (53%). Granulomas were seen in 61.2%. Glomeruli and peritubular capillaries were not affected in any of the biopsies. Reversible graft dysfunction was observed in 75% of cases, while mortality was noted in three patients.
conclusionAdenoviral nephritis is associated with diverse clinical manifestations with differing chronology post-transplantation. Graft dysfunction is associated with reversible interstitial nephritis. Further research is necessary to improve outcomes.
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